| Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis |
Ke Huang, Jiao Gao, Juan Du, Ning Ma, Yanling Zhu, Pengfei Wu,Tian Zhang,Wenqian Wang,Yuhang Li, Qianyu Chen, Andrew Paul Hutchins, Zhongzhou Yang, Yi Zheng,Jian Zhang, Yongli Shan, Xuejia Li, Baojian Liao, Jiajun Liu, Jinyong Wang, Bing Liu,Guangjin Pan |
2016 Nov |
Stem Cell Reports |
| Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors |
Zhen Wang, Huan Bian, Sergio G. Bartual, Wenting Du, Jinfeng Luo, Hu Zhao, Shasha Zhang, Cheng Mo, Yang Zhou, Yong Xu, Zhengchao Tu, Xiaomei Ren, Xiaoyun Lu, Rolf A. Brekken, Libo Yao, Alex N. Bullock, Jin Su, Ke Ding |
2016 Jun |
Journal of Medicinal Chemistry |
| 4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors |
Li Tan, Zhang Zhang, Donglin Gao, Jinfeng Luo, Zheng-Chao Tu, Zhengqiu Li, Lijie Peng, Xiaomei Ren,Ke Ding |
2016 Jul |
Journal of Medicinal Chemistry |
| CRISPR/Cas9 Facilitates Investigation of Neural Circuit Disease using Human iPSCs: Mechanism of Epilepsy Caused by an SCN1A Loss-of-function Mutation |
Liu J, Gao C, Chen W, Ma W, Deng S, Li X, Shi Y, Zhang H, Zhang L, Long Y, Xu H, Guo X, Lai L, Pan G, Chen Y, Liao W, Li Z |
2016 Jan |
Zhiyuan Li |
| Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models |
Manman Deng, Zhiwu Jiang, Yin Li, Yong Zhou, Jie Li, Xiangmeng Wang,Yao Yao, Weiguang Wang, Peng Li, Bing Xu |
2016 Dec |
oncotarget |
| Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity |
Xiaoyu Wang, Caijun Sun, Pingchao Li, Tongjin Wu, Hangyu Zhou, Dong Yang,Yichu Liu, Xiuchang Ma,Zhiyong Song, Qinggong Nian, Liqiang Feng,Chengfeng Qin, Ling Chen,Ruikang Tang |
2016 Jan |
Advanced Materials |
| Potent neutralizing monoclonal antibodies against Ebola virus infection |
Qi Zhang, Miao Gui, Xuefeng Niu, Shihua He, Ruoke Wang, Yupeng Feng, Andrea Kroeker, Yanan Zuo, Hua Wang, Ying Wang, Jiade Li, Chufang Li, Yi Shi, Xuanling Shi, George F. Gao, Ye Xiang, Xiangguo Qiu, Ling Chen,Linqi Zhang |
2016 May |
Scientific Reports |
| Simple and versatile synthetic polydopamine-based surface supports reprogramming of human somatic cells and long-term self-renewal of human pluripotent stem cells under defined conditions |
Ping Zhou,Fujian Wu, Tiancheng Zhou, Xiujuan Cai, Siqi Zhang, Xiaohong Zhang, Qiuhong Li, Yongliang Li, Yunfei Zheng, Mengke Wang, Feng Lan, Guangjin Pan, Duanqing Pei, Shicheng Wei |
2016 May |
Biomaterials |
| Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming |
Yi Wu,Keshi Chen, Xiyin Liu, Lili Huang, Danyun Zhao, Linpeng Li, Mi Gao,Duangqing Pei, Chenguang Wang, Xingguo Liu |
2016 Jan |
Stem Cells |
| Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming |
Zhongfu Ying,Keshi Chen,Lingjun Zheng,Yi Wu, Linpeng Li, Rui Wang, Qi Long, Liang Yang, Jingyi Guo, Deyang Yao, Yong Li, Feixiang Bao, Ge Xiang, Jinglei Liu, Qiaoying Huang, Zhiming Wu, Andrew Paul Hutchins,Duanqing Pei, Xingguo Liu |
2016 Jan |
Cell Metabolism |
| Pluripotency without Proliferation |
Xiaodong Shu, Duanqing Pei |
2016 Feb |
Cell |
| Copper-mediated C(sp3)–H azidation with Me3SiN3: synthesis of imidazoles from ketones and aldehydes.Chemical Communications |
Zeqiang Xie,Jiaojiao Deng,Zhiping Qiu,Juan Li,Qiang Zhu |
2016 May |
Chemical Communications |
| Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis |
Yiguang Zhu, Jinxin Xu, Xiangui Mei, Zhan Feng, Liping Zhang, Qingbo Zhang,Guangtao Zhang, Weiming Zhu, Jinsong Liu,Changsheng zhang |
2016 Apr |
ACS Chemical Biology |
| 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptictransmissions in human iPS-derived neurons |
Haitao Wang, Lingli Hu, Chunhua Liu, Zhenghui Su, Lihui Wang, Guangjin Pan, Yiping Guo, Jufang He |
2016 Feb |
Scientific Reports |
| Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder |
Di Li, Linli Wang, Jundi Hou, Qun Shen, Qianyu Chen, Xiaoshan Wang, Juan Du, Xiujuan Cai, Yongli Shan, Tian Zhang, Tiancheng Zhou, Xi Shi, Yuhua Li, Hua Zhang, Guangjin Pan |
2016 May |
Stem Cell Reports |
| TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells |
Lihui Wang, Xirui Li, Wenhao Huang, Tiancheng Zhou, Haitao Wang, Aiping Lin, Andrew Paul Hutchins1, Zhenghui Su, Qianyu Chen, Duanqing Pei, Guangjin Pan |
2016 Mar |
Scientific Reports |
| ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer |
Junjian Wang, June X Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C Yang, Maggie C Louie, Alexander D Borowsky, Allen C Gao, Christopher P Evans, Kit S Lam1, Jianzhen Xu, Hsing-Jien Kung, Ronald M Evans, Yong Xu, Hong-Wu Chen |
2016 May |
Nature Medicine |
| Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation |
Xiaoqian Xue, Yan Zhang, Zhaoxuan Liu, Ming Song, Yanli Xing, Qiuping Xiang, Zhen Wang, Zhengchao Tu, Yulai Zhou, Ke Ding, Yong Xu |
2016 Feb |
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| Generation of gene-target dogs using CRISPR/Cas9 system |
Qingjian Zou,Xiaomin Wang,YunzhongLiu,Zhen Ouyang, Haibin Long, Shu Wei,Jige Xin, Bentian Zhao, Sisi Lai, Jun Shen,Qingchun Ni, Huaqiang Yang, Huilin Zhong,Li Li, Minhua Hu, Quanjun Zhang, Zhidong Zhou, Jiaxin He, Quanmei Yan, Nana Fan,Yu Zhao, Zhaoming Liu, Lin Guo, Jiao Huang,Guanguan Zhang, Jun Ying, Liangxue Lai,Xiang Gao |
2015 Dec |
Journal of Molecular Cell Biology |
| Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells |
Wenbo Ma, Caiyue Li, Shikui Yin, Jingxin Liu, Chao Gao, Zuoxian Lin, Rongqi Huang, Jufang Huang, Zhiyuan Li |
2015 Dec |
Free Radical Biology and Medicine |
| Copper-Promoted Cycloaddition of α-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles |
Jian Wang, Jing Li,Qiang Zhu |
2015 Nov |
Organic Letters |
| Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for 'two-in-one' cancer chemoimmunotherapeutics |
Muzammal Hussain, Fei Tang, Jinsong Liu, Jiancun Zhang, Aqeel Javeed |
2015 Dec |
Cancer Letters |
| Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells |
Kaimeng Huang, Xiaobai Zhang, Jiejun Shi, Mingze Yao, Jiannan Lin, Jiao Li, He Liu, Huanhuan Li, Guang Shi, Zhibin Wang, Biliang Zhang, Jiekai Chen, Guangjin Pan, Cizhong Jiang, Duanqing Pei,Hongjie Yao |
2015 Dec |
Scientific Reports |
| SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains |
Yong-Heng Huang, Aleksander Jankowski, Kathryn S. E. Cheah, Shyam Prabhakar, Ralf Jauch |
2015 May |
Scientific Reports |
| Organocatalytic Enantioselective Michael Reaction of Malononitrile with beta,beta-Disubstituted Nitroalkenes |
Shengwei Chen,Qinxin Lou,Yuyang Ding,Shasha Zhang,Wenhui Hu,Junling Zhao |
2015 Aug |
Advanced Synthesis & Catalysis |
| Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether |
Yiwu Yao, Zheng Li, Yatao Qiu, Jinhong Bai, Jinyue Su, Dayong Zhang, Sheng Jiang |
2015 Sep |
Scientific Reports |
| Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities |
Yiwu Yao, Zhengchao Tu, Chenzhong Liao, Zhen Wang, Shang Li, Hequan Yao, Zheng Li, Sheng Jiang |
2015 Oct |
Journal of Medicinal Chemistry |
| An Enantioselective Synthesis of Spirobilactams through CopperCatalyzed Intramolecular Double N-Arylation and Phase Separation |
Jianguang Liu,Yingying Tian,Jialing Shi,Shasha Zhang,Qian Cai |
2015 Sep |
Angewandte Chemie-International Edition |
| Copper-Catalyzed Intramolecular Desymmetric Aryl C-O Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans |
Wenqiang Yang,Yangyuan Liu, Shasha Zhang,Qian Cai. |
2015 Jul |
Angewandte Chemie-International Edition |
| The oncogene c-Jun impedes somatic cell reprogramming |
Jing Liu, Qingkai Han, Tianran Peng,Meixiu Peng, BeiWei, Dongwei Li, XiaoshanWang,Shengyong Yu, Jiaqi Yang, Shangtao Cao, Kaimeng Huang, Andrew Paul Hutchins, He Liu,Junqi Kuang, Zhiwei Zhou, Jing Chen, HaoyuWu, Lin Guo, Yongqiang Chen, You Chen, Xuejia Li,HonglingWu, Baojian Liao,Wei He, Hong Song, Hongjie Yao, Guangjin Pan, Jiekai Chen，Duanqing Pei. |
2015 Jul |
Nature Cell Biology |
