| Discovery of the first examples of threonine tyrosine kinase PROTAC degraders |
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding. |
2022 |
Journal of Medicinal Chemistry |
| Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection |
Yudi Zhang, Qihong Yan, Kun Luo, Ping He, Ruitian Hou, Xinwei Zhao, Qian Wang, Haisu Yi, Huan Liang, Yijun Deng, Fengyu Hu, Feng Li, Xinglong Liu, Ying Feng, Pingchao Li, Linbing Qu, Zhaoming Chen, Qiang Pan-Hammarstr？m, Liqiang Feng,Xuefeng Niu,Ling Chen |
2022 |
Journal of Virology |
| Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer |
Xiang Q, Wang C, Wu T, Zhang C, Hu Q, Luo G, Hu J, Zhuang X, Zou L, Shen H, Wu X, Zhang Y, Kong X, Liu J, Xu Y |
2022 |
Journal of Medicinal Chemistry |
| Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway |
Tongjie Wang,Chengxiang Xia,Qitong Weng, Kaitao Wang,Yong Dong,Sha Hao,Fang Dong,Xiaofei Liu,Lijuan Liu,Yang Geng,Yuxian Guan,Juan Du,Tao Cheng,Hui Cheng and Jinyong Wang |
2022 |
Haematologica |
| Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation |
Qi Long, Yanshuang Zhou, Hao Wu, Shiwei Du, Mingli Hu, Juntao Qi, Wei Li, Jingyi Guo, Yi Wu, Liang Yang, Ge Xiang, Liang Wang, Shouhua Ye, Jiayuan Wen , Heng Mao, Junwei Wang, Hui Zhao, Wai-Yee Chan, Jinsong Liu, Yonglong Chen , Pilong Li, Xingguo Liu |
2021 Dec; |
NATURE STRUCTURAL & MOLECULAR BIOLOGY |
| Organocatalytic Asymmetric Arylation of p_x001e_Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands |
Guodong Sun, Zhuofei Deng, Zhonghua Luo, Zhongqing Wang,Jiancun Zhang |
2021 Oct; |
Organic Letters |
| Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption |
Chunxiu Wu, Yizi He, Jin Zhao, Kun Luo, Ziyu Wen, Yudi Zhang, Minchao Li, Yilan Cui , Zijian Liu, Congcong Wang, Zirong Han, Guangye Li, Fengling Feng, Pingchao Li, Ling Chen, Caijun Sun |
2021 Nov; |
Journal of Virology |
| HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6 |
Menghui Yin, Meidie Cheng, Chengli Liu, Keli Wu, Wei Xiong, Ji Fang, Yinxiong Li, Biliang Zhang |
2021 Oct; |
iScience |
| Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis |
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi |
2021 Oct; |
iScience |
| MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening |
Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei, Xingguo Liu, Keshi Chen |
2021 Nov; |
Cell Death & Differentiation |
| Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses |
Ruona Shi , Zhenhuan Feng , Xiaofei Zhang |
2021 Nov; |
Genomics Proteomics & Bioinformatics |
| Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation |
Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan WY, Liu J, Chen Y, Li P, Liu X |
2021 Oct; |
NATURE STRUCTURAL & MOLECULAR BIOLOGY |
| Capture of the newly transcribed RNA interactome using click chemistry |
Wang D, Yin M, Qin B, Zhang B, Bao X, Esteban MA |
2021 Oct; |
Nature Protocols |
| Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing |
Wang X, Liang Y, Zhao J, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J, Lai L |
2021 Oct; |
Cell Discovery |
| Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression |
Xu Y, Tao J, Yu X, Wu Y, Chen Y, You K, Zhang J, Getachew A, Pan T, Zhuang Y, Yuan F, Yang F, Lin X, Li YX |
2021 Oct; |
JCI Insight |
| Toll-like receptor 2 signaling in liver pathophysiology |
Getachew A, Hussain M, Huang X, Li Y |
2021 Nov; |
Life Sciences |
| SAGE1: a potential target antigen for lung cancer T-cell immunotherapy |
Li Y, Zhang Y, Yu X, Liu Q, Gong H, Chen AA, Zheng H, Zhong S |
2021 Aug; |
Molecular cancer therapeutics |
| Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity |
Zou Q, Qi H |
2021 Oct; |
International Journal of Biochemistry and Cell Biology |
| A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line anti-tuberculosis regimen |
Chiwala G, Liu Z, Mugweru JN, Wang B, Khan SA, Bate PNN, Yusuf B, Hameed HMA, Fang C, Tan Y, Guan P, Hu J, Tan S, Liu J, Zhong N, Zhang T |
2021 Aug; |
Biomedicine & Pharmacotherapy |
| Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis |
Wei Yu, Yusuf Buhari, Shuai Wang, Xirong Tian, H M Adnan Hameed, Zhili Lu, Gift Chiwala, Md Shah Alam, Gregory M Cook, Dmitry A Maslov, Nanshan Zhong, Tianyu Zhang |
2021 Sep; |
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| The mechanisms of action of Plasmodium infection against cancer |
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah |
2021 Jul; |
Cell Communication and Signaling |
| Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines |
Elena S Philonenko, Ying Tan, Cuihua Wang, Baoyun Zhang, Zahir Shah, Jianguang Zhang, Hanif Ullah, Sergei L Kiselev, Maria A Lagarkova, Dandan Li, Yong Dai,Igor M Samokhvalov |
2021 Aug; |
Journal of cellular and molecular medicine |
| SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappa B signalling activation |
Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang |
2021 Jul; |
CELL AND BIOSCIENCE |
| Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen |
Pengfei Liu , Shubin Chen , Yaofeng Wang , Xiaoming Chen, Yiping Guo, Chunhua Liu, Haitao Wang , Yifan Zhao, Di Wu, Yongli Shan , Jian Zhang, Chuman Wu , Dongwei Li, Yanmei Zhang, Tiancheng Zhou , Yaoyu Chen , Xiaobo Liu, Chenxu Li, Lihui Wang, Bei Jia, Jie Liu , Bo Feng, Jinglei Cai,Duanqing Pei |
2021 Mar; |
SCIENCE CHINA-LIFE SCIENCES |
| Nitric oxide-dependent electron transport chain inhibition by the cytochrome bc1 inhibitor and pretomanid combination kills Mycobacterium tuberculosis |
Sheng Zeng, Jingran Zhang, Mingwei Sun, Xiaofei Zhang, Gregory M Cook,Tianyu Zhang |
2021 Aug; |
Antimicrobial Agents and Chemotherapy |
| Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity |
Yue Xiong, Yan Chen, Xinping Huang, Zhen Yang, Jiaye Zhang, Xiaorui Yu , Ji Fang, Jiawang Tao, Kai You, Ziqi Cheng, Shenglin Tan, Yingying Xu, Fang Yuan, Ying Liu, Yuanqi Zhuang, Fan Yang, Yinxiong Li |
2021 Mar; |
Life Sciences |
| SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury |
Anteneh Getachew, Nasir Abbas, Kai You, Zhen Yang, Muzammal Hussain,Xinping Huang, Ziqi Cheng, Shenglin Tan, Jiawang Tao, Xiaorui Yu, Yan Chen,Fan Yang, Tingcai Pan, Yingying Xu, Guosheng Xu, Yuanqi Zhuang, FeiMa Wu,Yinxiong Li |
2021 Apr; |
iScience |
| AP-1 activity is？a？major barrier of？human somatic cell reprogramming |
Yuting Liu, Jiangping He, Ruhai Chen, He Liu, Jocelyn Chen, Yujian Liu, Bo Wang, Lin Guo, Duanqing Pei, Jie Wang, Jing Liu, Jiekai Chen |
2021 Aug; |
Cellular and Molecular Life Sciences |
| Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients |
Qihong Yan, Pingchao Li, Xianmiao Ye, Xiaohan Huang, Bo Feng, Tianxing Ji, Zhilong Chen, Feng Li, Yudi Zhang, Kun Luo, Fengjuan Chen, Xiaoneng Mo, Jianhua Wang, Liqiang Feng, Fengyu Hu, Chunliang Lei, Linbing Qu, Ling Chen |
2021 May; |
Journal of Immunology |
| Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats |
Chunhua Liu, Xiaoyun Wang, Wenhao Huang, Wei Meng, Zhenghui Su, Qi Xing, Heng Shi, Di Zhang, Min Zhou, Yifan Zhao, Haitao Wang, Guangjin Pan, Xiaofen Zhong, Duanqing Pei,Yiping Guo |
2021 Jul; |
Stem Cell Research & Therapy |
