| IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells |
Zhiwu Jiang, Rui Liao, Jiang Lv, Shanglin Li, Diwei Zheng, Le Qin, Di Wu, Suimin Chen, Youguo Long, Qiting Wu, Suna Wang, Simiao Lin, Xiaohan Huang, Zhaoyang Tang, Pengcheng Shi, Hongsheng Zhou, Qifa Liu, Ruocong Zhao, Yangqiu Li, Yang Jie, Wei Wei, Peilong Lai, Xin Du, Shuzhong Cui, Robert Weinkove, Pentao Liu, Duanqing Pei, Yao Yao, Peng Li |
2021 May; |
Leukemia |
| Mucosal Priming with a Recombinant Influenza A Virus-Vectored Vaccine Elicits T-Cell and Antibody Responses to HIV-1 in Mice |
Jinlin Wang,Tao Shu,Weiqi Deng,Yali Zheng,Min Liao,Xianmiao Ye,Lujie Han,Ping He,Xuehua Zheng,Ting Li,Ying Feng,Fengyu Hu,Pingchao Li,Caijun Sun,Ling Chen,Feng Li,Liqiang Feng |
2021 May; |
Journal of Virology |
| A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice |
Xianmiao Ye,Xinglong Liu,Tao Shu,Weiqi Deng,Min Liao,Yali Zheng,Xuehua Zheng,Xiaoyan Zhang,Ting Li,Wenxia Fan,Linbing Qu,Ling Chen, Feng Li, Liqiang Feng |
2021 Jun; |
Journal of Virology |
| Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist |
Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li , Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu , Donghai Wu, Jinsong Liu, Yong Xu |
2021 Jun; |
JOURNAL OF MEDICINAL CHEMISTRY |
| Palladium-Catalyzed Enantioselective 7- exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzo[ b, d]azepin-6-ones |
Huaanzi Hu, Yan Peng, Ting Yu, Sidi Cheng, Shuang Luo, Qiang Zhu |
2021 May; |
organic letters |
| RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes |
Qing Xia, Guizhong Cui , Ye Fan, Xiuqin Wang, Gongcheng Hu, Lisha Wang , Xi Luo, Lele Yang, Qingqing Cai, Kaibiao Xu , Wenjing Guo, Minghui Gao, Yingying Li, Ji Wu , Wei Li, Jiayu Chen 9 , Huayu Qi, Guangdun Peng , Hongjie Yao |
2021 May; |
Cell Proliferation |
| Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans |
Yamin Gao, H M Adnan Hameed, Yang Liu, Lingmin Guo, Cuiting Fang, Xirong Tian, Zhiyong Liu, Shuai Wang , Zhili Lu, Md Mahmudul Islam, Tianyu Zhang |
2021 Mar; |
Acta Pharmaceutica Sinica B |
| Global Profiling of the Lysine Crotonylome in Different Pluripotent States |
Yuan Lv, Chen Bu, Jin Meng, Carl Ward, Giacomo Volpe, Jieyi Hu, Mengling Jiang, Lin Guo , Jiekai Chen, Miguel A Esteban, Xichen Bao, Zhongyi Cheng |
2021 Mar; |
GENOMICS PROTEOMICS & BIOINFORMATICS |
| Generation of UCiPSC-derived neurospheres for cell therapy and its application |
Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian , Feng Tang, Zhiyuan Li |
2021 Mar; |
Stem Cell Research & Therapy |
| Robust expansion and functional maturation of human hepatoblasts by chemical strategy |
Tingcai Pan, Jiawang Tao , Yan Chen, Jiaye Zhang , Anteneh Getachew, Yuanqi Zhuang, Ning Wang , Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang , Xianhua Lin, Kai You , Yi Gao, Yin-Xiong Li |
2021 Feb; |
Stem Cell Research & Therapy |
| Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors |
Minhao Huang, Yongjun Huang, Jing Guo, Lei Yu, Yu Chang, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang, Zhang Zhang, Ke Ding |
2021 Feb; |
European journal of medicinal chemistry |
| Rapid visualized assessment of drug efficacy in live mice with a selectable marker-free autoluminescent Klebsiella pneumoniae |
Xirong Tian, Yamin Gao, Shuai Wang, H M Adnan Hameed, Wei Yu, Cuiting Fang, Jingran Zhang, Yaoju Tan, Zhizhong Cao , Ping Guan, Jinxing Hu , Jianxiong Liu, Nanshan Zhong, Tianyu Zhang |
2021 Apr; |
BIOSENSORS & BIOELECTRONICS |
| The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity |
Jiadong Liu, Mingwei Gao, Jiangping He, Kaixin Wu, Siyuan Lin, Lingmei Jin, Yaping Chen, He Liu, Junjie Shi, Xiwei Wang, Lei Chang, Yingying Lin, Yu-Li Zhao, Xiaofei Zhang, Man Zhang, Guan-Zheng Luo, Guangming Wu, Duanqing Pei, Jie Wang, Xichen Bao, Jiekai Chen |
2021 Mar; |
Nature |
| A General Strategy for the Construction of Calyciphylline A-Type Alkaloids: Divergent Total Syntheses of (-)-Daphenylline and (-)-Himalensine A |
Bingyang Wang, Bo Xu, Wen Xun, Yiming Guo , Jing Zhang, Fayang G Qiu |
2021 Apr; |
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
| Palladium-Catalyzed Atroposelective Coupling–Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones |
Fan Teng, Ting Yu, Yan Peng, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo, and Qiang Zhu |
2021 Feb; |
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY |
| ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems |
Jingke Xie,Xingyun Huang,Xia Wang,Shixue Gou,Yanhui Liang,Fangbing Chen,Nan Li,Zhen Ouyang,Quanjun Zhang,Weikai Ge,Qin Jin,Hui Shi,Zhenpeng Zhuang,Xiaozhu Zhao,Meng Lian,Jiaowei Wang,Yinghua Ye,Longquan Quan,Han Wu,Kepin Wang,Liangxue Lai |
2020 Sep; |
BMC Biology |
| Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation |
Xiaomin Wang,Hui Shi,Juanjuan Zhou,Qingjian Zou,Quanjun Zhang,Shixue Gou,Pengfei Chen,Lisha Mou,Nana Fan,Yangyang Suo,Zhen Ouyang,Chengdan Lai,Quanmei Yan,Liangxue Lai |
2020 May; |
Journal of Genetics and Genomics |
| In vivo therapeutic effects of affinity-improved-TCR engineered T-cells on HBV-related hepatocellular carcinoma |
Qi Liu,Ye Tian,Yanyan Li,Wei Zhang,Wenxuan Cai,Yaju Liu,Yuefei Ren,Zhaoduan Liang,Peipei Zhou,Yajing Zhang,Yifeng Bao,Yi Li |
2020 Dec; |
Journal for ImmunoTherapy of Cancer |
| Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells |
Yanling Zhu,Tianyu Wang,Jiaming Gu,Ke Huang,Tian Zhang,Zhishuai Zhang,He Liu,Jun Tang,Yuchan Mai,Yanqi Zhang,Yuhang Li,Yashu Feng,Baoqiang Kang,Jinbing Li,Yongli Shan,Qianyu Chen,Jian Zhang,Bing Long, Junwei Wang,Minghui Gao,Di Zhang,Min Zhou,Xiaofen Zhong,Jiekai Chen,Duanqing Pei,Jinfu Nie,Bing Liu,Guangjin Pan |
2020 Dec; |
Cell Discovery |
| Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD + redox |
Liang Yang,Xiaobing Lin,Haite Tang,Yuting Fan,Sheng Zeng,Lei Jia,Yukun Li,Yanan Shi,Shujing He,Hao Wang,Zhijuan Hu,Xiao Gong,Xiaoyan Liang,Yi Yang,Xingguo Liu |
2020 Sep; |
Aging Cell |
| Sustainable Approach to Azaheterocyclic Acetamides by Decarboxylative Aminoformylation |
Zhenxing Zhang,Chunqi Jia,Xiangtao Kong,Muzammal Hussain,Zhenyu Liu,Wanqing Liang,Ling Jiang,Hao Jiang,Junyan Ma |
2020 Nov; |
ACS Sustainable Chemistry & Engineering |
| NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting |
Yong Dong,Kaitao Wang,Qitong Weng,Tongjie Wang,Peiqing Zhou,Xiaofei Liu,Yang Geng,Lijuan Liu,Hongling Wu,Jinyong Wang,Juan Du |
2020 Sep; |
Cell Proliferation |
| Pd-Catalyzed Domino Imidoylation/Heck/C(sp2)-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center |
Fan Teng,Yan Peng,Xilong Wang,Weiming Hu,Huaanzi Hu,Yimiao He,Shuang Luo,Qiang Zhu |
2020 Nov; |
Organic Letters |
| Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming |
Xiaowei Lai,Qian Li,Fang Wu,Jiechun Lin,Jiekai Chen,Hui Zheng,Lin Guo |
2020 Aug; |
Frontiers in Cell and Developmental Biology |
| Mesenchymal Stem Cells Suppress Leukemia via Macrophage-Mediated Functional Restoration of Bone Marrow Microenvironment |
Chengxiang Xia,Tongjie Wang,Hui Cheng,Yong Dong,Qitong Weng,Guohuan Sun,Peiqing Zhou,Kaitao Wang, Xiaofei Liu,Yang Geng,Shihui Ma,Sha Hao,Ling Xu,Yuxian Guan,Juan Du,Xin Du,Yangqiu Li,Xiaofan Zhu,Yufang Shi,Sheng Xu,Demin Wang,Tao Cheng,Jinyong Wang |
2020 Sep; |
Leukemia |
| β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus |
Meng Zhang,Yiwei Lai,Vladislav Krupalnik,Pengcheng Guo,Xiangpeng Guo,Jianguo Zhou,Yan Xu,Zhijun Yu,Longqi Liu,Ao Jiang,Wenjuan Li,Mazid Md Abdul,Gang Ma,Na Li,Xiuling Fu,Yuan Lv,Mengling Jiang,Muqddas Tariq,Shahzina Kanwal,Hao Liu,Xueting Xu,Hui Zhang,Yinghua Huang,Lulu Wang,Shuhan Chen,Isaac A Babarinde,Zhiwei Luo,Dongye Wang,Tiantian Zhou,Carl Ward,Minghui He,David P Iba？ez,Yunpan Li,Jiajian Zhou, Jie Yuan,Yayan Feng,Karthik Arumugam,Umberto Di Vicino,Xichen Bao,Guangming Wu,Axel Schambach,Huating Wang,Hao Sun,Fei Gao,Baoming Qin,Andrew P Hutchins,Bradley W Doble,Christine Hartmann, Maria Pia Cosma,Yan Qin,Guo-Liang Xu,Runsheng Chen,Giacomo Volpe,Liang Chen,Jacob H Hanna,Miguel A Esteban |
2020 Jul; |
Science Advances |
| JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency |
Yinghua Huang,Hui Zhang,Lulu Wang,Chuanqing Tang,Xiaogan Qin,Xinyu Wu,Meifang Pan,Yujia Tang,Zhongzhou Yang,Isaac A Babarinde,Runxia Lin,Guanyu Ji,Yiwei Lai,Xueting Xu,Jianbin Su,Xue Wen,Takashi Satoh, Tanveer Ahmed,Vikas Malik,Carl Ward,Giacomo Volpe,Lin Guo,Jinlong Chen,Li Sun,Yingying Li,Xiaofen Huang, Xichen Bao,Fei Gao,Baohua Liu,Hui Zheng,Ralf Jauch,Liangxue Lai,Guangjin Pan,Jiekai Chen,Giuseppe Testa,Shizuo Akira,Jifan Hu,Duanqing Pe,Andrew P Hutchin,Miguel A Esteban,Baoming Qin |
2020 Oct; |
Nature Communication |
| Tandem [5 + 2]/[4 + 2] Cycloadditions To Construct the [6-7-6] Tricyclic Skeleton of Icetexane Diterpenes: Total Synthesis of Euolutchuol E, Przewalskine E and Brussonol |
Jing Zhang,Yehua Jin,Fayang G Qiu |
2020 Oct; |
Organic letters |
| YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways |
Jiadong Liu,Mingwei Gao,Shuyang Xu,Yaping Chen,Kaixin Wu,He Liu,Jie Wang,Xuejie Yang,Junwei Wang,Weiwei Liu,Xichen Bao,Jiekai Chen |
2020 Sep; |
Cell Reports |
| Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions |
Gongcheng Hu,Xiaotao Dong,Shixin Gong,Yawei Song,Andrew P Hutchins,Hongjie Yao |
2020 Sep; |
Nucleic Acids Research |
