国家自然科学基金-面上项目（2021-2024，2024-2027），项目负责人

国家自然科学基金-青年科学基金项目（2020-2022），项目负责人

广东省重大人才工程青年项目（2025-2028），项目负责人

广东省自然科学基金-面上项目（2019-2022，2022-2024），项目负责人

广州市基础研究计划（2021-2023，2025-2026），项目负责人

国家重点研发计划-合成生物学重点专项（2025-2029），项目骨干

国家重点研发计划-干细胞及转化研究重点专项（2018-2022），项目骨干

1. Wu Y#*, Liu Y#, Huang Y#, Hao Z, Li W, Li Y, Zhang M, Li L, Qin D, Chen K, Liu X*. Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells. Cell Discovery, 2026, 12, 7

2. Hao Z#, Wu Y#, Huang Y#, Zhang M#, Liu Y, Li Y, Li W, Ruan Z, Zhang J, Ding Y, Li L, Xing G, Liu Z, Zhou Y, Wang Q, Chen K, Wang W, Lu G, Qin D, Chan WY, Liu X*. Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development. Nature Communications, 2025, 16(1), 10324.

3. Wu Y#, Chen K#, Li L#, Hao Z#, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X*. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 2022, 29(11), 2312-2331. (CDD Press Readers’ Choice)

4. Wu Y#, Chen K#, Xing G, Li L, Ma B, Hu Z, Duan L, Liu X*. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances, 2019, 5(11), eaax7525.

5. Liao R#, Wu Y#, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X*, Li P*. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal, 2023, 42(21), e113448. 

6. Li L#, Chen K#, Wang T#, Wu Y#, Xing G, Chen M, Hao Z, Zhang C, Zhang J, Ma B, Liu Z, Yuan H, Liu Z, Long Q, Zhou Y, Qi J, Zhao D, Gao M, Pei D, Nie J, Ye D, Pan G, Liu X*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Nature Metabolism, 2020, 2(9), 882-892. (ESI Highly Cited, Biology & Biochemistry Top 1%)

7. Wu Y#, Liu Y#, Hao Z, Liu X*. NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine, 2022, 1(3), 401-405. (Most Picked Paper Award 2022)

8. Li L#*, Sun S#, Wu Y#, Lu J#, He J, Chen K, Chan WY, Liu X*. Lactate and protein lactylation: the ugly duckling of energy as the sculpture artist of proteins. Science Bulletin, 2023, 68(21), 2510-2514. (Cover)

9. Li L#, Chen K#, Wu Y#, Xiang G, Liu X*. Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes. Journal of Genetics and Genomics, 2022, 49(4), 279-286.

10. Wu Y#, Chen K#, Liu X, Huang L, Zhao D, Li L, Gao M, Pei D, Wang C, Liu X*. Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming. Stem Cells, 2016, 34(1), 83-92. 

11. Ding H#, E T#, He J#, Wu Y#, Zheng X, Duan L*, Liu X*, Li L*. An exquisite symphony: protein post-translational modifications govern mitochondrial fate. Element, 2026, 1, 13.

12. Wu Y, Chen K, Xiang G, Ying Z, Liu X*. Organelle remodeling during the acquistion and loss of pluripotency. Science Foundation in China, 2020, 28(1), 47-55. (Cover)