1. 肿瘤进展过程中的细胞命运转变（增殖+转移）。

2. 肿瘤细胞增殖和转移的体内外模型构建。

3. EMT转变和表观遗传的交互调控。

1. 国家自然科学基金青年基金项目（2017年），项目负责人。

2. 广州市科技计划项目（2021年），项目负责人。

(1) Li, Changpeng#*; Meng, Fei*; He, Jingcai*; Dong, Linna*; He, Yuexian; Guo, Qing; Zeng, Kerou; Wu, Yanhua; Ge, Haofei; Chen, Shiyu; Yang, Tingting; Zhou, Yusheng; Wang, Yulu; Liu, Lin; Ren, Qiwen; He, Meiai; Sun, Hao; Liang, Lining; Guo, Lin; Li, Xiaolin; Hong, Jiahong; Huang, Zhenhua#; Zheng, Hui#; Cytoplasm-nucleus shuttling of TET2: an intrinsic brake in colorectal cancer progression, Cell Death & Disease, 2026, 17(1) (期刊论文) ( 本人标注: 共同第一作者, 共同通讯作者 )

(2) Changpeng Li#*; Jingcai He*; Fei Meng*; Fuhui Wang*; Hao Sun; Huizhong Zhang; Linna Dong; Mengdan Zhang; Qiaoran Xu; Lining Liang; Yuan Li; Tingting Yang; Meiai He; Tao Wang; Jiechun Lin; Jiaqi Sun; Qiuling Huang; Lin Guo; Xiaofei Zhang; Shijuan Ma#i; Hui Zheng#; Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer, Cell Death & Disease, 2023, 14(8) (期刊论文) (共同第一作者, 共同通讯作者 )。

(3) Jiang, Lijuan*; Dong, Pei*; Zhang, Zhilin*; Li, Changpeng*; Li, Yi; Liao, Yiji; Li, Xiaomin; Wu, Zhi; Guo, Shua; Mai, Shijuan; Xie, Dan; Liu, Zhuowei; Zhou, Fangjian#; Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells., Cell Death & Disease, 2015, 6(8): e1660 (期刊论文) (共同第一作者 )