2021-至今 中国科学院广州生物医药与健康研究院 副研究员

2018 -2020 中国科学院广州生物医药与健康研究院 博士后

2015- 2018 广州医科大学/呼吸疾病国家重点实验室 博士

2011-2015 中国科学院广州生物医药与健康研究院 研究实习员/助理研究员

2008-2011 沈阳药科大学/军事医学科学院生物工程研究所 硕士

2004-2008 山东第一医科大学 学士

病毒疫苗与免疫

1. 国家自然科学基金重点项目，92269201，2023-2026，合作方负责人

2. 国家自然科学基金面上项目，32370171，2024-2027，负责人

3. 国家自然科学基金青年项目，32000124，2021-2023，负责人

4. 中国博士后特别资助项目，2020T130115ZX，2018-2020，负责人

5. 中国博士后基金面上项目，2019M663140，2018-2020，负责人

6. 广东省自然科学基金面上项目，2021A1515010456， 2021-2023，负责人

7. 广东省科技攻关应急专项，2020B111109004， 2020-2021，子课题负责人

8. 中国科学院青促会项目，2022361，2022-2025，负责人

代表论著：^#共同第一作者，*通讯作者

1. Chen S^#, Zhang Z^#, Wang Q^#, Yang Q^#, Yin L, Ning L, Chen Z, Tang J, Deng W, He P, Li H, Shi L, Deng Y, Liu Z, Bu H, Zhu Y, Liu W, Qu L, Feng L, Xiong X, Sun B, Zhong N, Li F, Li P^*, Chen X^*, Chen L^*. 2024. Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies. Signal Transduct Target Ther 9:190.
2. Li H^#, Yang C^#, Yin L, Liu W, Zhang Z, Liu B, Sun X, Liu W, Lin Z, Liu Z, He P, Feng Y, Wang C, Wang W, Guan S^*, Wang Q^*, Chen L^*, Li P^*. 2024. Comparative immunogenicity of monovalent and bivalent adenovirus vaccines carrying spikes of early and late SARS-CoV-2 variants. Emerg Microbes Infect.
3. Wen Z^#, Li P^#, Yuan Y^#, Wang C^#, Li M, Wang H, Shi M, He Y, Cui M, Chen L^*, Sun C^*. 2024. Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques. eLife. DOI: 10.7554/eLife.95964
4. Wang Q^#, Yang C^#, Yin L^#, Sun J^#, Wang W^#, Li H, Zhang Z, Chen S, Liu B, Liu Z, Shi L, Liu X, Guan S, Wang C, Qu L, Feng Y, Niu X, Feng L, Zhao J^*, Li P^*, Chen L^*, Zhong N. 2023. Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants. Signal Transduct Target Ther 8:167.
5. Li P^#*, Wang Q^#, He Y^#, Yang C^#, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L^*, Chen L^*. 2023. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerg Microbes Infect 12:e2136538.
6. Jie F^#, Wu X^#, Zhang F^#, Li J^#, Liu Z, He Y, Li C, Zhang H, Lin Y, Zhu X, Yu H, Liu Y, Li Z, Qu L^*, Chen L^*, Li P^*. 2023. Influenza Virus Infection Increases Host Susceptibility To Secondary Infection with Pseudomonas aeruginosa, and This Is Attributed To Neutrophil Dysfunction through Reduced Myeloperoxidase Activity. Microbiol Spectr 11:e0365522.
7. He Y^#, Wu C^#, Liu Z^#, Zhang Y, Feng F, Lin Z, Wang C, Yang Q, Wen Z, Liu Y, Zhang F, Lin Y, Zhang H, Qu L, Li L, Cai W, Sun C^*, Chen L^*, Li P^*. 2023. Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques. Microbiol Spectr 11:e0052523.
8. Liu W^#, Li H^#, Liu B^#, Lv T^#, Yang C, Chen S, Feng L, Lai L, Duan Z, Chen X, Li P^*, Guan S^*, Chen L^*. 2023. A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine. Emerg Microbes Infect 12:2233643.
9. Yu P^#, Liu Z^#, Zhu Z^#, Yang J^#, Deng M^#, Chen M, Lai C, Kong W, Xiong S, Wan L, Mai W, Chen L, Lei Y, Khan SA, Ruan J, Kang A, Guo X, Zhou Q, Li W, Chen Z^*, Liang Y^*, Li P^*, Zhang L^*, Ji T^*. 2023. Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees. Virol Sin 38:233-243.
10. Zhang L^#, Yang J^#, Lai C^#, Wan L^#, Xiong S^#, Kong W^#, Liu Z, Yu P, Chen M, Mai W, Khan SA, Deng M, Chen L, Lei Y, Zhou Q, Yu N^*, Li P^*, Chen Z^*, Ji T^*. 2023. Immunity against Delta and Omicron variants elicited by homologous inactivated vaccine booster in kidney transplant recipients. Front Immunol 13:1042784.
11. Wang H^#, Li P^#, Zhang M, Bi J, He Y, Li F, Yu R, Gao F, Kong W, Yu B^*, Chen L^*, Yu X^*. 2022. Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques. Microb Biotechnol 15:2022-2039
12. Wu C^#, He Y^#, Zhao J^#, Luo K, Wen Z, Zhang Y, Li M, Cui Y, Liu Z, Wang C, Han Z, Li G, Feng F, Li P^*, Chen L^*, Sun C^*. 2021. Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption. J Virol 96:e0178521
13. Li M^#, Yuan Y^#, Li P^#, Deng Z, Wen Z, Wang H, Feng F, Zou H, Chen L, Tang S^*, Sun C^*. 2022. Comparison of the Immunogenicity of HIV-1 CRF07_BC Gag Antigen With or Without a Seven Amino Acid Deletion in p6 Region. Front Immunol 13:850719.
14. Wu C, Zhao J, Li R, Feng F, He Y, Li Y, Huang R, Li G, Yang H, Cheng G, Chen L, Ma F, Li P^*, Sun C^*. 2021. Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques. Virol Sin 36(5):1197-1209
15. Yan Q^#, Li P^#, Ye X^#, Huang X^#, Feng B, Ji T, Chen Z, Li F, Zhang Y, Luo K, Chen F, Mo X, Wang J, Feng L, Hu F, Lei C^*, Qu L^*, Chen L^*. 2021. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. J Immunol 206:2146-2159.
16. Yang Q^#, Feng F^#, Li P^#, Pan E, Wu C, He Y, Zhang F, Zhao J, Li R, Feng L, Hu F, Li L, Zou H, Cai W, Lehner T*, Sun C*, Chen L*. 2019. Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. Adv Sci (Weinh) 6:1900319.
17. Zhang F, Wang L, Niu X, Li J, Luo J, Feng Y, Yang Y, He P, Fan W, Liang R, Zheng Z, Pan W, Li C, Tan YJ, Yu H, Chen L^*, Li P^*. 2019. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol 10:2426.
18. Li P, Feng F, Pan E, Fan X, Yang Q, Guan M, Chen L^*, Sun C^*. 2018. Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection. Virology 519:86-98.
19. Wang X^#, Sun C^#, Li P, Wu T, Zhou H, Yang D, Liu Y, Ma X, Song Z, Nian Q, Feng L, Qin C*, Chen L*, Tang R*. 2016. Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity. Adv Mater 28:694-700.