万力研究员于2010年进入浙江大学生命科学研究院黄俊教授实验室攻读博士学位，期间主要利用细胞生物学手段研究DNA损伤修复的分子机制。随后，前往英国弗朗斯西克里克研究所，加入了Jesper Svejstrup（英国皇家科学学会和医学会院士）实验室从事博士后研究。在此期间，曾到剑桥大学Manu Hegde（英国皇家科学学会院士）实验室进行访问学习，主要从事天然免疫应答与蛋白质合成相关分子机制的研究。2022年10月，万力研究员在中国科学院广州生物医药与健康研究院成立了自己的研究团队。本团队采用了细胞生物学、分子生物学与生物化学、免疫学等学科的交叉渗透研究方式，并结合体外翻译技术、定量蛋白质组学、CRISPR介导的基因敲除、核糖体分析技术等创新手段，系统性研究天然免疫应答与蛋白质合成的分子机制。万力研究员先后主持了两个国家级项目，并主持或参与了多项省、市级重要科研项目，曾获得的浙江省自然科学一等奖和EMBO-Long Term Fellowship。
2014 Innovation Center for Cell signalling network, Speaker. USTC campus, Hefei, China
2018 EMBO Fellow’s Meeting, Speaker. EMLB campus, Heidelberg, Germany
2019 EMBO Workshop, “Protein Quality Control” Poster presenter, Mallorca, Spain
2020 Cold Spring Harbor Laboratory, “Translational control” Speaker, Virtual conference
主要作者论文：
1)Jin-Gen Xu, Shi Chen, Yang He, Xi Zhu, Yanting Wang, Zhifeng Ye, Jin-Chuan Zhou, Xuanhui Wu, Lei Zhang, Xiaochen Ren, Huifeng Jia,Haijia Yu, Xiaoyue Wei, Yujie Feng,….Xiangyang Zhu#, Yifan Zhan#, Li Wan#. (2024) An Antibody Cocktail Targeting Two Different CD73 Epitopes Enhances Enzyme Inhibition and Tumor Control. Nature Communications. (#corresponding author) accepted in principle.
2) Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius. Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell. 81(13):2808-2822.
3) Jinhua Han*, Li Wan*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S.Y. Huen, Ting Liu, and Jun Huang. (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc Natl Acad Sci USA (*co-first author).
4) Li Wan, and Jun Huang. (2014) The PSO4 complex associates with RPA and modulates the activation of ATR. J Biol Chem, 289: 6619-6626.
5) Li Wan*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Reports, 14: 1104-1112. (*co-first author) .
6) Li Wan*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc Natl Acad Sci USA, 110: 10646-10651. (*co-first author).
7) Ting Liu*, Li Wan*, Yue Wu, Junjie Chen, Jun Huang. (2011) hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem, 286: 41758-41766. (*co-first author).
其他论文：
1) Zhong Han , George A Moore , Richard Mitter , David Lopez Martinez , Li Wan , A Barbara Dirac Svejstrup , David S Rueda , Jesper Q Svejstrup. (2023). DNA-directed termination of RNA polymerase II transcription. Molecular Cell, 83(18) 3253-3267
2) Szymon Juszkiewicz, Shaun Speldewinde, Li Wan, Jesper Svejstrup, and Ramanujan S Hegde. (2020) The ASC-1 complex disassembles collided ribosomes. Molecular Cell, 79: 603-614.
3) Daniil Bespalov, Dayana Pino, Sònia Vidal-Guirao, Júlia Franquesa, Daniel Lopez-Ramajo, Ingrid Filgaira, Li Wan, Paul A O'Sullivan , Steven C Ley , Sonia Vanina Forcales , Juan José Rojas , Mercè Izquierdo-Serra , Concepció Soler, Joan Manils. (2024) Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer. Scientific Reports,14(1):22972.
