广州市科技计划科技菁英“领航”项目（2025年），项目负责人。

国家重点研发计划项目（2024年），课题负责人。

国家自然科学基金面上项目（2024年），项目负责人。

国家优秀青年科学基金项目（2020年），项目负责人。

国家自然科学基金面上项目（2020年），项目负责人。

国家重点研发计划项目（2019年），项目负责人。

国家青年科学基金项目（2015年），项目负责人。

广东省自然科学奖一等奖（2025年）

广州市高层次人才“杰出专家”（2022年）

国家自然科学基金优秀青年（2020年）

中国新锐科技人物（2018年）

中国科学院杰出科技成就奖（2017年，主要完成者）

中国科学院广州分院优秀青年科技工作者（2016年）

广东省科学技术一等奖（2015年）

广州市科学技术一等奖（2015年）

广州市珠江科技新星（2014年）

（一作及通讯作者）

1.  Zhang, X., Y. Li, R. Luo, H. Wang, J. Guo, X. Zhang, M. Kumar, Y. Li and J. Liu* (2026). "Dietary Periodicity Disrupts the Gut Microbiota-Enterolactone Axis to Exacerbate MASLD in a Translational Guinea Pig Model." Nutrients 18(15):2573.

2.  Wang, L*., L. Xiao, G. Zou, H. Mao, S. Zhang, Q. Yang, C. Yin, J. Wan, M. Kumar, H. Wu, H. Wang, X. Zhang, L. Zeng, C. Zhou, S. Yu, Y. Li, L. Zheng, Y. Liu, B. Liao, Z. Zhang* and J. Liu* (2026). "Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human." Nat Commun 17(1):4215.

3.  Wang, H., Y. Li, C. Yin, Z. Zhang, Y. Wang, Y. Li, C. Li, R. Lin, X. Zhang, J. Guo, R. Luo, S. Li, L. Zhang, Y. Zhuang, A. Xu, J. Wan, L. Xiao, B. Chen, S. Yu, M. Kumar* and J. Liu* (2026). "Dose‑resolved control of somatic reprogramming by Rora." Stem Cell Reports 21(4):102870.

4.   Chen, Z., Y. Huang, Z. Yuan, K. Xu, Y. Guan, L. Wang, Y. Jiang, W. Deng, Y. Pan, J. Liu* and Y. Hu* (2025). "Induced pluripotent stem cells carrying novel APTX mutations presented defective neural differentiation with the accumulation of DNA single-strand breaks." Cell Death Discovery 11(1):481.

5.   Guo, J., R. Lin, J. Liu, R. Liu, S. Chen, Z. Zhang, Y. Yang, H. Wang, L. Wang, S. Yu, C. Zhou, L. Xiao, R. Luo, J. Yu, L. Zeng, X. Zhang, Y. Li, H. Wu, T. Wang, Y. Li, M. Kumar*, P. Zhu* and J. Liu* (2025). "Capture primed pluripotency in guinea pig." Stem Cell Reports 20(2):102388.

6.   Xiao, L., Z. Huang, Z. Wu, Y. Yang, Z. Zhang, M. Kumar, H. Wu, H. Mao, L. Lin, R. Lin, J. Long, L. Zeng, J. Guo, R. Luo, Y. Li, P. Zhu, B. Liao*, L. Wang* and J. Liu* (2024). "Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression." Nat Commun 15(1):10787.

7.   Liu, Y., S. Zhang, G. Zou, J.An, Y.Li, D.Li, D.Lin, D.Wang, Y.Li, J.Chen, T.Feng, H.Li, Y.Chen, M.Zhang, M.Kumar, L.Wang*, R.Hou* and J. Liu* (2024). "Generation and characterization of giant panda induced pluripotent stem cells". Sci Adv 10(38):eadn7724.

8.   Guan, T., J. Guo, R. Lin, J. Liu, R. Luo, Z. Zhang*, D. Pei* and J. Liu* (2024). "Single-cell analysis of preimplantation embryonic development in guinea pigs." BMC Genomics 25(1): 911.

9.   Li, C., X. Xu, S. Chen, A. Xu, T. Guan, H. Wu*, D. Pei* and J. Liu* (2024). "Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation." Cell Biosci 14(1): 9.

10.  Lin, R., Z. Zhai, J. Kuang, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei* and J. Liu* (2022). "H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition." Cell Biosci 12(1): 89.

11.  Wu, H., C. Li, M. Masood, Z. Zhang, E. Gonzalez-Almela, A. Castells-Garcia, G. Zou, X. Xu, L. Wang, G. Zhao, S. Yu, P. Zhu, B. Wang, D. Qin* and J. Liu* (2022). "Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation." Cells 11(15):2460.

12.  Yu, S., C. Zhou, J. He, Z. Yao, X. Huang, B. Rong, H. Zhu, S. Wang, S. Chen, X. Wang, B. Cai, G. Zhao, Y. Chen, L. Xiao, H. Liu, Y. Qin, J. Guo, H. Wu, Z. Zhang, M. Zhang, X. Zhao, F. Lan, Y. Wang, J. Chen, S. Cao*, D. Pei* and J. Liu* (2022). "BMP4 drives primed to naive transition through PGC-like state." Nat Commun 13(1): 2756.

13.  Kuang, J., Z. Zhai, P. Li, R. Shi, W. Guo, Y. Yao, J. Guo, G. Zhao, J. He, S. Xu, C. Wu, S. Yu, C. Zhou, L. Wu, Y. Qin, B. Cai, W. Li, Z. Wu, X. Li, S. Chu, T. Yang, B. Wang, S. Cao, D. Li, X. Zhang, J. Chen, J. Liu* and D. Pei* (2021). "SS18 regulates pluripotent-somatic transition through phase separation." Nat Commun 12(1): 4090.

14.  Liu, Y., J. He, R. Chen, H. Liu, J. Chen, Y. Liu, B. Wang, L. Guo, D. Pei, J. Wang, J. Liu* and J. Chen* (2021). "AP-1 activity is a major barrier of human somatic cell reprogramming." Cell Mol Life Sci. 78(15):5847-5863.

15.  Fu, M., H. Chen, Z. Cai, Y. Yang, Z. Feng, M. Zeng, L. Chen, Y. Qin, B. Cai, P. Zhu, C. Zhou, S. Yu, J. Guo, J. Liu*, S. Cao* and D. Pei* (2021). "Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency." Cell Regen 10(1): 17.

16.  Wu, L., G. Zhao, S. Xu, J. Kuang, J. Min, G. Wu, T. Wang, B. Wang, P. Zhu, D. Pei* and J. Liu* (2020). "The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure." J Biol Chem 296:100022.

17.  Yu, S., C. Zhou, S. Cao, J. He, B. Cai, K. Wu, Y. Qin, X. Huang, L. Xiao, J. Ye, S. Xu, W. Xie, J. Kuang, S. Chu, J. Guo, H. Liu, W. Pang, L. Guo, M. Zeng, X. Wang, R. Luo, C. Li, G. Zhao, B. Wang, L. Wu, J. Chen, J. Liu* and D. Pei* (2020). "BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling." Nat Cell Biol 22(6): 651-662.

18.  Wang, B., L. Wu, D. Li, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu* and D. Pei* (2019). "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4." Cell Rep 27(12): 3473-3485.

19.  Cao, S., S. Yu, D. Li, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen, J. Liu* and D. Pei* (2018). "Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency." Cell Stem Cell 22(4): 529-542 .

20.  Wang, B., D. Li, J. Chen, J. Liu* and D. Pei* (2018). "Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension." Cell Regen 7(1): 16-21.

21.  Li, D., J. Liu, X. Yang, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins*, J. Chen* and D. Pei* (2017). "Chromatin Accessibility Dynamics during iPSC Reprogramming." Cell Stem Cell 21(6): 819-833.

22.  Cao, S., S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qin, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu* and D. Pei* (2017). "Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage." J Biol Chem 292(46): 19122-19132.

23.  Liu, J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A. P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen* and D. Pei* (2015). "The oncogene c-Jun impedes somatic cell reprogramming." Nat Cell Biol 17(7): 856-867.

24.  Ouyang, J., W. Yu, J. Liu, N. Zhang, L. Florens, J. Chen, H. Liu, M. Washburn, D. Pei and T. Xie (2015). "Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state." J Biol Chem 290(37): 22782-22794.

25.  Chen, J., J. Liu, Y. Chen, J. Yang, J. Chen, H. Liu, X. Zhao, K. Mo, H. Song, L. Guo, S. Chu, D. Wang, K. Ding and D. Pei (2011). "Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics." Cell Res 21(6): 884-894.

26.  Chen, J., J. Liu, J. Yang, Y. Chen, J. Chen, S. Ni, H. Song, L. Zeng, K. Ding and D. Pei (2011). "BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone." Cell Res 21(1): 205-212.

27.  Chen, J., J. Liu, Q. Han, D. Qin, J. Xu, Y. Chen, J. Yang, H. Song, D. Yang, M. Peng, W. He, R. Li, H. Wang, Y. Gan, K. Ding, L. Zeng, L. Lai, M. A. Esteban and D. Pei (2010). "Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells." J Biol Chem 285(40): 31066-31072.

（其他作者论文）

1.  Guo, L, J Lin, Q Ren, H Sun, Y Wu, H Ge, X Wu, L Lin, L Liang, C Li, H Liu, Y Mai, S Chu, J Liu, J Liu, J Chen, D Pei, H Zheng (2025). Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase. Adv Sci 12(32):10.1002/advs.202415528.

2.  Ming, J, L Lin, J Li, L Wu, S Fang, T Huang, Y Fu, D Liu, W Zhang, C Li, Y Yang, Y Huang, Y Qin, J Kuang, X Huang, L Guo, X Zhang, J Liu, J Chen, C Zhao, B Wang, D Pei (2024). Cell fate decision by a morphogen‑transcription factor‑chromatin modifier axis. Nat Commun 15(1):6365.

3.  Kuang, J, P Li, Z Zhai, Y Fan, H Xu, C Zhao, W Li, X Li, Z Liang, T Huang, Y Qin, H Gao, Z Ma, D Liu, G Zhong, B Wang, J Liu, J Wang, M Tortorella, B Liao, D Pei (2024). Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates. Mol Cancer 23(1):85.

4.  Fu, Y, F Jiang, X Zhang, Y Pan, R Xu, X Liang, X Wu, X Li, K Lin, R Shi, X Zhang, D Ferrandon, J Liu, D Pei, J Wang, T Wang (2024). Perturbation of METTL1‑mediated tRNA N7‑methylguanosine modification induces senescence and aging. Nat Commun 15(1):5713.

5.  Yang, Y, L Xiao, Y Xue, M Idris, J Liu, D Pei, Y Shi, B Liao, F Li (2023). ZBTB7A regulates primed‑to‑naive transition of pluripotent stem cells via recognition of the PNT‑associated sequence by zinc fingers 1‑2 and recognition of γ‑globin‑200 gene element by zinc fingers 1‑4. FEBS J 290(15):3896‑3909.

6.  Wang, B, C Li, J Ming, L Wu, S Fang, Y Huang, L Lin, H Liu, J Kuang, C Zhao, X Huang, H Feng, J Guo, X Yang, L Guo, X Zhang, J Chen, J Liu, P Zhu, D Pei (2023). The NuRD complex cooperates with SALL4 to orchestrate reprogramming. Nat Commun 14(1):2846.

7.  Xing, G, Z Liu, L Huang, D Zhao, T Wang, H Yuan, Y Wu, L Li, Q Long, Y Zhou, Z Hao, Y Liu, J Lu, S Li, J Zhu, B Wang, J Wang, J Liu, J Chen, D Pei, X Liu, K Chen (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b‑phosphorylation dependent heterochromatin loosening. Cell Death Differ 29(5):1042‑1054.

8.  Zhang, X, L Chen, X Huang, H Chen, B Cai, Y Qin, Y Chen, S Ou, X Li, Z Wu, Z Feng, M Zeng, W Guo, H Li, C Zhou, S Yu, M Pan, J Liu, K Kang, S Cao, D Pei (2022). MYOCD is Required for Cardiomyocyte‑like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin. Stem Cell Rev Rep 18(7):2414‑2430.

9.  Qin, Y, X Huang, Z Cai, B Cai, J He, Y Yao, C Zhou, J Kuang, Y Yang, H Chen, Y Chen, S Ou, L Chen, F Wu, N Guo, Y Yuan, X Zhang, W Pang, Z Feng, S Yu, J Liu, S Cao, D Pei (2022). Regeneration of the human segmentation clock in somitoids in vitro. EMBO J 41(23):e110928.

10.  Li, J, W Jiang, H Han, J Liu, B Liu, Y Wang (2021). ScGSLC: An unsupervised graph similarity learning framework for single‑cell RNA‑seq data clustering. Comput Biol Chem 90:107415.

11.  Lu, S, Z Zhang, P Du, L Chard, W Yan, M El Khouri, Z Wang, Z Zhang, Y Chu, D Gao, Q Zhang, L Zhang, A Nagano, J Wang, C Chelala, J Liu, J Chen, P Liu, Y Dong, S Wang, X Li, J Dong, N Lemoine, D Pei, Y Wang (2020). A Virus‑Infected, Reprogrammed Somatic Cell‑Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer. Clin Cancer Res 26(2):465‑476.

12.  Guo, L, L Lin, X Wang, M Gao, S Cao, Y Mai, F Wu, J Kuang, H Liu, J Yang, S Chu, H Song, D Li, Y Liu, K Wu, J Liu, J Wang, G Pan, A Hutchins, J Liu, D Pei, J Chen (2019). Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single‑Cell RNA‑Seq. Mol Cell 73(4):815‑+.

13.  Shi, Z, S Xu, S Xing, K Yao, L Zhang, L Xue, P Zhou, M Wang, G Yan, P Yang, J Liu, Z Hu, F Lan (2019). Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes. FASEB J 33(11):13040‑13050.

14.  Zhou, Z, X Yang, J He, J Liu, F Wu, S Yu, Y Liu, R Lin, H Liu, Y Cui, C Zhou, X Wang, J Wu, S Cao, L Guo, L Lin, T Wang, X Peng, B Qiang, A Hutchins, D Pei, J Chen (2017). Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex‑Dependent Function. Cell Rep 21(8):2160‑2170.

15.  Liu, X, H Sun, J Qi, L Wang, S He, J Liu, C Feng, C Chen, W Li, Y Guo, D Qin, G Pan, J Chen, D Pei, H Zheng (2013). Sequential introduction of reprogramming factors reveals a time‑sensitive requirement for individual factors and a sequential EMT‑MET mechanism for optimal reprogramming. Nat Cell Biol 15(7):829‑+.

16.  Chen, J, L Guo, L Zhang, H Wu, J Yang, H Liu, X Wang, X Hu, T Gu, Z Zhou, J Liu, J Liu, H Wu, S Mao, K Mo, Y Li, K Lai, J Qi, H Yao, G Pan, G Xu, D Pei (2013). Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet 45(12):1504‑U140.

17.  Chen, J, H Liu, J Liu, J Qi, B Wei, J Yang, H Liang, Y Chen, J Chen, Y Wu, L Guo, J Zhu, X Zhao, T Peng, Y Zhang, S Chen, X Li, D Li, T Wang, D Pei (2013). H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet 45(1):34‑U62.

18.  Wang, Q, X Xu, J Li, J Liu, H Gu, R Zhang, J Chen, Y Kuang, J Fei, C Jiang, P Wang, D Pei, S Ding, X Xie (2011). Lithium, an anti‑psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res 21(10):1424‑1435.

19.  Wang, Y, J Chen, J Hu, X Wei, D Qin, J Gao, L Zhang, J Jiang, J Li, J Liu, K Lai, X Kuang, J Zhang, D Pei, G Xu (2011). Reprogramming of mouse and human somatic cells by high‑performance engineered factors. EMBO Rep 12(5):373‑378.

 专利

1. 稳定传代的豚鼠多能干细胞及其制备方法，申请号：2024119734513，申请日：2024.12.30，申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：刘晶、郭婧、罗蓉苹、林润霞；

2. 诱导体细胞重编程的因子及诱导体细胞重编程的方法，申请号：202311831064.1，申请日：2023.12.27，申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：刘晶、肖立展、黄子芬、王鲁勤、茆慧萍；

3.  一种诱导多能干细胞由始发态进入基态的方法及培养基体系，申请号：202410353071.3，申请日：2024.03.26，申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：刘晶、王鲁勤、邹高阳、肖立展、茆慧萍；

4. 一种制备大熊猫诱导性多能干细胞的培养基体系及方法，申请号：202410353067.7，申请日：2024.03.26，申请（专利权）人：中国科学院广州生物医药与健康研究院，成都大熊猫繁育研究基地；发明人：刘晶、张世豪、刘玉良、邹高阳、王鲁勤、安俊辉、李媛；

5. 诱导体细胞重编程的因子以及使用该因子诱导体细胞重编程的方法；专利号: ZL 201910327535.2；申请日：2019.04.23；授权公告日：2023.11.24；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；刘晶；王波；吴琳琳；

6. 诱导体细胞重编程的因子以及使用该因子诱导体细胞重编程的方法；专利号：ZL 201910188173.3申请日：2019.03.13；授权公告日：2023.11.07；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；刘晶；王波；吴琳琳；刘雨婷；

7. 一种用于化学诱导多能性干细胞生成的培养体系以及使用该培养体系的化学重编程方法。申请号：201810170553.X；申请日：2018.03.01；申请（专利权）人：中国科学院广州生物医药与健康研究院 ；发明人：裴端卿；曹尚涛；刘晶；余胜勇；陈捷凯；叶晶；李东伟；

8. 一种用于制备内胚层细胞系的培养体系以及制备内胚层细胞系的方法；申请号：201710814001.3；申请日：2017.09.11；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；刘晶；曹尚涛；余胜勇；陈捷凯；

9. 一种制备诱导多能性干细胞的方法以及该方法中所使用的组合物及其应用；专利号：ZL 201310574447.5申请日：2013.11.15；授权公告日：2019.10.01；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；刘晶；陈捷凯；彭梅秀；

10.  c-Jun的N端缺失诱导多能性干细胞的方法和应用；专利号：ZL 201210324576.4；申请日：2012.09.04；授权公告日：2013.10.16；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；韩庆凯；刘晶；陈捷凯；韦备；彭梅秀；

11.  c-Jun的截短型维持胚胎干细胞多能性的方法和应用；专利号：ZL 201210324215.X；申请日：2012.09.04；授权公告日：2013.12.04       ；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；刘晶；韩庆凯；陈捷凯；韦备；彭梅秀；

12.  一种培养基添加剂及其应用；专利号：ZL 201010167062.3；申请日：2010.04.30；授权公告日：2015.06.03；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；陈捷凯；刘晶；

13.  骨形成蛋白在诱导诱导式多能性干细胞过程中的应用；专利号： ZL 201010510485.0；申请日：2010.10.18    ；授权公告日：2014.05.14；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；陈捷凯；刘晶；

14.  诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法；专利号：ZL200910038883.4；申请日：2009.04.23 ；授权公告日：2012.02.29；申请（专利权）人：中国科学院广州生物医药与健康研究院；发明人：裴端卿；陈捷凯；刘晶；