2009年博士毕业于中国科学院上海生物化学与细胞生物学研究所，美国加州大学洛杉矶分校（UCLA）博士后；回国后在中国科学院上海生物化学与细胞生物学研究所先后担任助理研究员、副研究员。2018年9月入职中国科学院广州生物医药与健康研究院，担任研究员、课题组长、博士生导师。主持国家重点研发计划项目、广东省基础与应用基础研究重大项目（基石）等。为国家重点高层次青年人才、广东省杰青、中国发育生物学专业委员会副秘书长、谱系技术与装备研究中心执行副主任、人类细胞谱系大科学设施副总工艺师。
“细胞学说”指出“所有生命体皆由细胞组成”，“细胞是生命的基本单元”以及“所有细胞都由此前的细胞变化而来”等核心概念，成为现代生物学的重要基石。然而，细胞的身份如何定义、细胞的过去现在和未来如何精确解码—这些细胞的“谱系信息”在漫长的科学研究长河中，一直是科学中的重要和基本问题并没有得到很好的解答。捕获细胞谱系的多维信息，尤其是探究其在时间、空间维度的精确动态变化，是探索生命奥秘、解析发育程式、治愈疾病、延缓衰老的基础；对细胞谱系的精准操控，是基于细胞治疗、器官重建的未来再生医学应用之不可或缺的前提。本实验室围绕细胞的时空动态谱系问题，主要开展以下研究：
研究方向一：单细胞多组学与谱系示踪技术解析细胞谱系的功能分群与异质性
结合单细胞多组学测序、单细胞谱系示踪、生物信息学、人工智能以及类器官等手段重点关注发育与组织损伤中特定功能细胞的动态变化与细胞谱系决定的调控机制。
研究方向二：原位空间多组学技术解析空间功能特异的细胞调控特征
发展和利用高通量、高分辨率的空间多组学技术，研究组织功能实现的细胞基础，揭示原位、动态、多维度的细胞命运决定与调控网络。
研究方向三：新型多能干细胞用于体外器官重建与功能修复
基于细胞谱系的新发现，实现谱系再造、损伤修复与器官的体外重建。
主要学术成果
聚焦细胞的时空动态谱系研究，以技术与数据驱动生物学新发现。开发了多种空间组学原创技术，绘制了小鼠着床后胚胎三个胚层建立过程高分辨率的时空动态分子图谱，揭示了多能干细胞的发育调控网络，解析了小鼠大脑的时空动态谱系发育过程，发现了新型的组织干细胞可用于体外器官重建与组织修复。发表研究论文及综述七十余篇，通讯作者论文发表在《Nature》《Cell》《Nature Methods》《Nature Genetics》《Annals of the Rheumatic Disease》《Developmental Cell》《Nature Communications》《Cell Reports》等，研究成果获选“中国生命科学十大进展”、“2中国生物信息学十大进展”及“中国生物信息学十大应用”等。
国际干细胞学会（ISSCR）会员
中国动物学会发育生物学专业委员会副秘书长
Sanofi-SIBS 2017 Distinguished Young Faculty
ISSCR 2017 Poster Award and Travel Award
国家级人才项目
中国生命科学十大进展
中国生物信息学十大进展
1. Lin L, Zhong J, Jiang F, Wang Y, Ma L, Yang J, Li Y, Gao R-R, Feng H, Cai B, Feng Z, Zhou X, Shu Y, Chen P, Wu X, Cai C-L, Wang Q, Wu G, Pei D*, Cao S*, Liu Y*, Peng G*, Chen J* & Chen Q* (2026) A single-cell time-series atlas of endothelial cell embryonic development. Cell, S0092867426000498.
2. Qian Y, Zhu M, Ren C, Zhou Y, Xu J, Dong L, Zhang G, Li C, Lv J, Xing Q*, Zhang G*, Peng G* & Liao N* (2026) Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer. Genomics, Proteomics & Bioinformatics, qzag001.
3. Guo C-K, Xia C-R, Peng G*, Cao Z-J* & Gao G* (2025) Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE. Small Methods, e2401451.
4. Meng X, Li W, Xu J, Yao Y, Gong A, Yang Y, Qu F, Guo C, Zheng H, Cui G*, Suo S* & Peng G* (2025) Spatiotemporal transcriptome atlas of developing mouse lung. Science Bulletin 70, 1641–1658.
5. Ke J, Xu J, Liu J, Yang Y, Guo C, Xie B, Cui G, Peng G* & Suo S* (2025) High-resolution mapping of single cells in spatial context. Nat Commun 16, 6533.
6. Yang X, Li C, He J, Xie B, Lv L, Xu J, Lin Y, Zhou C, Li M, Zeng Z, Tan J, Chen S, Cui G, Liu G*, Suo S*, Peng G* & Liang X* (2025) Spatial and single-cell transcriptomics landscape of adenomyosis. Journal of Advanced Research, S209012322501032X.
7. Chen C, Liao Y, Zhu M, Wang L, Yu X, Li M & Peng G* (2025) Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a. Cell Reports 44, 115105.
8. Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G*, Yan X*, Wang Y* & Zhang M* (2025) Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Advanced Science, 2413019.
9. Jiang F, Wang H, Li Z, Cui G & Peng G* (2024) Leveraging spatial multiomics to unravel tissue architecture in embryo development. Trends in Genetics, S0168952524002713.
10. Zou S, Peng G* & Ma Z* (2024) Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies. Nanomaterials.
11. Wang Z, Li Z, Luan T, Cui G, Shu S, Liang Y, Zhang K, Xiao J, Yu W, Cui J, Li A*, Peng G* & Fang Y* (2024) A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2. Developmental Cell 59, 2787-2803.e8.
12. Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Annals of the Rheumatic Diseases 83, 926–944.
13. Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K & Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods 20, 1048–1057.
14. Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S* & Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun 14, 4599.
15. Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G* & Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen 12, 15.
16. Meng X, Cui G* & Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen 12, 5.
17. Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C* & Chen Z-J* (2022) Single-cell technologies: From research to application. The Innovation 3, 100342.
18. Chen C, Liao Y & Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell 13, 790–807.
19. Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N* & Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports 40, 111285.
20. Li Z & Peng G* (2022) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports 8, 119–135.
21. Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G* & Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation 54, e13000.
22. Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G* & Qiao Y* (2021) Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo. Cell Proliferation 54, e13096.
23. Peng G*, Cui G, Ke J & Jing N* (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genom Hum Genet 21, 163–181.
24. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H* & Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 51, 728–738.
25. Peng G*, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han J-DJ* & Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature 572, 528–532.
26. Cui G, Jing N & Peng G* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo.’ Journal of Molecular Cell Biology 11, 1024–1025.
27. Peng G* & Han J-DJ* (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res 7, 1477.
28. Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL* & Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ 60, 463–472.
29. Peng G* & Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci 60, 363–369.
30. Chen J, Suo S, Tam PP, Han J-DJ*, Peng G* & Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc 12, 566–580.
完整论文情况Google scholar: https://scholar.google.com/citations?user=s7XddBgAAAAJ
实验室英文主页：https://gpenglab.github.io/penglab/
