研究方向聚焦于真核生物转录调控相关复合物的结构与功能研究，特别关注与肿瘤发生发展密切相关的、调控转录活性的重要蛋白质复合物。迄今，以并列/第一作者或者通讯作者在Nature、 Science、 Nature Structural & Molecular Biology、 Cell Research、 Nature Communications、 PNAS 等国际高影响力期刊发表研究论文数十篇。研究工作得到国家自然科学基金面上项目和青年项目等资助，入选上海市浦江人才计划。

研究组将围绕“非编码RNA的动态特征与功能机制”这一核心，开展以下三个层次的研究：首先，在多尺度上解析其转录与加工的动态特征；其次，揭示其参与形成的功能网络与调控机制；最终，基于上述发现，致力于开发基于RNA的精准诊断方法与治疗靶点。

2025-2029 国家自然科学基金面上项目

2020-2022 国家自然科学基金青年项目

2019-2021 上海市浦江人才计划项目（A类）

2015年度国家优秀自费留学生奖学金

2021年上海交通大学医学院“九龙医学优秀青年人才奖”

1. Wang Q, Ren Y, Jin Q, Chen X#, Xu Y#. Structural insights into human Pol III transcription initiation in action. Nature, 2025, 643(8073):1127-1134  

2. Wang Q*, Li S*, Wan F*, Xu Y*, Wu Z, Cao M, Lan P#, Lei M#, Wu J#. Structural insight into transcription regulation of human RNA polymerase III. Nature Structural&Molecular Biology, 2021, 28:220-227

3. Wang Q, Taschner M, Ganzinger K, Kelley C, Villasenor A, Heymann M, Schwille P, Lorentzen E, Mizuno N. Membrane association and remodeling by intraflagellar transport protein IFT172. Nature communications, 2018, 9(1)

4. Wang Q, Crevenna A, Kunze I, Mizuno N. Structural basis for the extended CAP-Gly domains of p150glued binding to microtubules and the implication for tubulin dynamics. Proceedings of the National Academy of Sciences, 2014, 111(31): 11347-11352

5. Chen X*, Liu W*, Wang Q*, Wang X*, Ren Y, Qu X, Li W, Xu Y. Structural visualization of transcription initiation in action. Science, 2023, 382(6677):eadi5120

6. Li Y*, Wang Q*, Xu Y, Li Z. Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nature Communications, 2024, 15(1):4622

7. Wan F*, Wang Q*, Tan J*, Tan M, Chen J, Shi S, Lan P#, Wu J #, Lei M #. Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. Nature communications, 2019,10(1)

8. Chen K*, Wang L*#, Yu Z*, Yu J, Ren Y, Wang Q#, Xu Y#. Structure of the human TIP60 complex. Nature Communications, 2024, 15(1):7092

9. Hou H*, Jin Q*, Ren Y*, Chen Z, Wang Q#, Xu Y#. Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Cell Research, 2023, 33(7):565-568

10. Wang L*, Yu J*, Yu Z*, Wang Q*, Li W, Ren Y, Chen Z#, He S#, Xu Y#. Structure of nucleosome-bound human PBAF complex. Nature Communications, 2022, 13(1):7644

11. Wang Q, Lei M, Wu J. A structural perspective of human RNA polymerase III. RNA Biology, 2022, 19(1):246-255

12. Wang Q*, Daiss L J*, Xu Y#, Engle C#. Snapshots of RNA polymerase III in action-a mini review. Gene, 2022, 821:146282

13. Su H*, Wang Q*, Li C, Li K, Luo W, Chen B, Zhang X, Qin Q, Zhou B, Chen X, Zhang Y, Xie B. Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2017, 1858(4): 325-335

14. Wu J*, Niu S*, Tan M*, Huang C, Li M, Song Y, Wang Q, Chen J, Shi S, Lan P#, Lei M#. Cryo-EM structure of the human ribonuclease P holoenzyme. Cell, 2018, 175(5):1393-1404

15. Yao T, Jing W, Hu Z, Tan M, Cao M, Wang Q, Li Y, Yuan G, Lei M, Huang J. Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome. Cell Research, 2019, 29(4):330-333