实验室（更多内容见实验室主页https://jiewanglab.github.io/us/index.html）以多组学检测、生物信息学分析结合实验验证的交叉手段，研究疾病发生与器官再生的调控机制，主要涉及以下研究内容：

1. 检测类器官等损伤修复模型的多组学图谱，并开发新算法分析组学数据。

2. 多组学分析结合功能实验揭示疾病发生与器官再生的表观调控机制。

3. 构建调控疾病发生与器官再生的数字模型，发现有效的基因干预靶点。

课题组围绕疾病发生和器官再生相关的表观组，开发了组学整合、调控网络重构等新方法，揭示了神经退化和再生修复的表观调控图谱，并部分实现了哺乳动物的视网膜再生。在Science, Nature Communications, Briefings in Bioinformatics等杂志发表多篇研究论文，包括2篇ESI高被引论文。（#共同第一作者，*共同通讯作者）

1. Hoang T^#, Wang J^#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR^*, Qian J^*, Blackshaw S^*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 2020, 370(6519): eabb8598.
2. Wang J^#, Zibetti C^#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S^*, Qian J^*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications 2018, 9(1): 1-13.
3. Jiang J^#, Li J^#, Huang S, Jiang F, Liang Y, Xu X^*, Wang J^*. CACIMAR: cross-species analysis of cell identities, markers, regulations, and interactions using single-cell RNA sequencing data. Briefings in Bioinformatics 2024, 25(1): bbae283.
4. Fu Y^#, Jiang F^#, Zhang X, Pan Y, Xu R, Liang X, Wu X, Li X, Lin K, Shi R, Zhang X, Ferrandon D, Liu J, Pei D, Wang J^*, Wang T^*. Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging. Nature Communications 2024, 15(1): 1-21.
5. Jiang J^#, Lyu P^#, Li J^#, Huang S, Tao J, Blackshaw S, Qian J, Wang J^*. IReNA: integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience 2022, 25(11): 105359.