1.国家杰出青年科学基金项目（2022年），项目负责人。

2.国家重点研发计划（2019年），项目负责人（首席科学家）。

3.国家优秀青年科学基金项目（2015年），项目负责人。

4.国家重大科学研究计划（973）青年项目（2014年），项目负责人。

5.国家自然科学基金面上项目（2017年、2013年），项目负责人。

6.广东省自然科学基金杰出青年基金，项目负责人。

7.广东省重大专项计划，项目负责人。

8.广州市科技计划项目重点项目，项目负责人。

（*为通讯作者），以下工作更新于2021年3月份，完整论文信息请见https://pubmed.ncbi.nlm.nih.gov/?term=jiekai+chen

2021年

1.       Jiadong Liu^#; Mingwei Gao^#; Jiangping He^#; Kaixin Wu; Siyuan Lin; Lingmei Jin; …; Jiekai Chen*; The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, Nature, 2021, 591(7849): 322-326. (发现RNA m6A调控异染色质和干细胞的新功能) 

2. Jiangping He; …; Andrew P. Hutchins*; Jiekai Chen*; Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE, Nature Communications, 2021, 12(1): 1456. (开发单细胞测序分析转座元件的新工具) 

3.   Feng-Liang Liu^#; Kaixin Wu^#; Jiaoyang Sun^#; Zilei Duan^#; Xiongzhi Quan; …; Guangming Wu*; Yong-Tang Zheng*; Jiekai Chen*; Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, National Science Review, 2021. （新一代动物模型技术，35天制备新冠易感小鼠）

4.   Xianwen Ren^#; Wen Wen^#; Xiaoying Fan^#; …; Hongyang Wang*; Bing Su*; Zheng Zhang*; Kun Qu*; Xiaoqun Wang*; Jiekai Chen*; Ronghua Jin*; Zemin Zhang*; COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Cell, 2021. (新冠肺炎单细胞研究中国联盟，限于篇幅未列出所有重要作者) 

2020年

5.   Kaixin Wu^#; He Liu^#; Yaofeng Wang; Jiangping He; …; Jiekai Chen*; SETDB1-Mediated Cell Fate Transition between 2C- Like and Pluripotent States, Cell Reports, 2020, 30(1): 25-36. (发现H3K9甲基化酶SETDB1调控干细胞多能性和全能性)

6.       Jiadong Liu^#; Mingwei Gao^#; …; Jiekai Chen*; YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Cell Reports, 2020, 32(10): 108120. 

7.       Jiekai Chen*; Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity, Current Opinion in Genetics & Development, 2020, 64: 21-25.

8.       Jiangping He^#; Shuijiang Cai^#; Huijian Feng^#; Baomei Cai^#; Lihui Lin^#; Yuanbang Mai; …; Nanshan Zhong; Xinwen Chen*; Xilong Deng*; Jiekai Chen*; Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients, Protein & Cell, 2020, 11(9): 680-687.

9.       Xiaowei Lai^#; Qian Li^#; Fang Wu; Jiechun Lin; Jiekai Chen*; Hui Zheng*; Lin Guo*; Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming, Front Cell Dev Biol, 2020 , 8:760.

10.    Linlin Hou*; Yuanjie Wei; …; Jiekai Chen; Xichen Bao*; Ralf Jauch*; Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2, Nucleic Acids Research, 2020, 48(7): 3869-3887.

11.    Jing Sun^#; Zhen Zhuang^#; Jian Zheng^#; …; Jiekai Chen; Yimin Li; Nanshan Zhong; David K. Meyerholz; Paul B. McCray, Jr.*; Stanley Perlman*; Jincun Zhao*; Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment, Cell, 2020, 182(3): 734-+.

12.    Shengyong Yu^#; Chunhua Zhou^#; Shangtao Cao^#; Jiangping He^#; …; Jiekai Chen; Jing Liu*; Duanqing Pei*; BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling, Nature Cell Biology, 2020, 22(6): 651-+.

2013-2019年

13. Lin Guo^#; Lihui Lin^#; Xiaoshan Wang^#; Mingwei Gao; Shangtao Cao; Yuanbang Mai; Fang Wu; …; Duanqing Pei*; Jiekai Chen*; Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq, Molecular Cell, 2019, 73(4): 815-829. (建立SOT算法，对iPS重编程过程的细胞命运决定过程进行了新阐述)

14.    Zhiwei Zhou; Xuejie Yang; Jiangping He; …; Andrew P. Hutchins; Duanqing Pei*; Jiekai Chen*; Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function, Cell Reports, 2017, 21(8): 2160-2170.

15.    Dongwei Li^#; Jing Liu^#; Xuejie Yang^#; …; Andrew P. Hutchins*; Jiekai Chen*; Duanqing Pei*; Chromatin Accessibility Dynamics during iPSC Reprogramming, Cell Stem Cell, 2017, 21(6): 819-833.

16.    Jing Liu; Qingkai Han; Tianran Peng; …; Guangjin Pan; Jiekai Chen*; Duanqing Pei*; The oncogene c-Jun impedes somatic cell reprogramming, Nature Cell Biology, 2015, 17(7): 856-867.

17.    Jiangping He; Xiuling Fu; Meng Zhang; …; Jiekai Chen; Miguel A. Esteban; Andrew P. Hutchins*; Transposable elements are regulated by contextspecific patterns of chromatin marks in mouse embryonic stem cells, Nature Communications, 2019, 10(1): 34.

18.    Alejandro De Los Angeles^#; Francesco Ferrari^#; …; Jiekai Chen; Marti Borkent; Vladislav Krupalnik; Ernesto Lujan; Marius Wernig; Jacob H. Hanna; Konrad Hochedlinger; Duanqing Pei; Rudolf Jaenisch; Hongkui Deng; Stuart H. Orkin; Peter J. Park*; George Q. Daley*; Failure to replicate the STAP cell phenomenon, Nature, 2015, 525(7570): E6-9.

19.    Mengyun Zhang^#; Yong Dong^#; Fangxiao Hu^#; …; Jiekai Chen; Aibin He; Bing Liu; Demin Wang; Yong-Guang Yang; Jinyong Wang*; Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes, Nature Immunology, 2018, 19(3): 279-290.

20.    Shangtao Cao^#; Shengyong Yu^#; Dongwei Li^#; Jing Ye; Xuejie Yang; …; Guangjin Pan; Jiekai Chen; Jing Liu*; Duanqing Pei*; Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency, Cell Stem Cell, 2018, 22(4): 529-542.

21.    Jiekai Chen^#; He Liu^#; Jing Liu; Jing Qi; Bei Wei; Jiaqi Yang; Hanquan Liang; You Chen; et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs, Nature Genetics, 2013, 45(1): 34-42. （首次阐明H3K9甲基化是重编程的重要障碍，ESI高引论文）

22.    Jiekai Chen^#; Lin Guo^#; Lei Zhang^#; Haoyu Wu; Jiaqi Yang; He Liu; et al. Vitamin C modulates TET1 function during somatic cell reprogramming, Nature Genetics, 2013, 45(12): 1504-1509. （阐明Vc对Tet1的功能的转化作用，当期杂志配发评论）