2002年-2006年：清华大学生物科学与技术系，博士
1998年-2002年：山东大学生命科学学院，学士
2007年-2010年: Thomas Jefferson University, 博士后
2010年－至今： 中国科学院广州生物医药与健康研究院 研究员
干细胞命运调控中的核与线粒体等细胞器重塑
人类线粒体疾病的病理与干细胞治疗
Science Bulletin（《科学通报》英文版）执行编委
FASEB Journal、MedComm编委
亚洲线粒体研究与医学学会 副理事长
中国生物物理学会 常务理事
中国生物物理学会 线粒体生物学分会 会长
中国生物医学工程学会干细胞工程技术分会 副主任委员
国家重点研发计划“发育编程及其代谢调节” 、“合成生物学”专项指南编制专家组成员
·国家自然科学“杰出青年“基金
·国家重点研发计划首席科学家（2项）
·成果入选中国科学院年度工作报告（生命医学领域共11项）
·广东省科学技术奖自然科学一等奖（第一完成人）
·树兰医学青年奖
·丁颖科技奖
·政府特殊津贴
·中国细胞生物学学会-普洛麦格创新基金
·2016年干细胞青年研究员奖
·广东省自然科学杰出青年基金获得者（首届）
·国际生物物理学会 "2011 Young Bioenergeticist award"
·广东省精准医学奖自然科学一等奖（第一完成人）
·广东省生物医药健康促进会科学技术奖“杰出青年奖”
·中国科学院广州教育基地优秀研究生导师
·中国科学院广州分院优秀青年科学家
1. Du, S., Long Q.*, Zhou,Y.,…Liu, X*.(2026). Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models. Cell, Mar 18:S0092-8674(26)00230-8. doi: 10.1016/j.cell.2026.02.023. (新华社通稿)
2. Hu, Z., Yang, L., Zhang, M.,…Liu, X*. (2024). A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metabolism, 36(7):1586-1597.e7. (Cell Metabolism当期专文评述)
3. Ying, Z., Xiang G., Zheng, L., …Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.
4. Ying, Z., Chen K., Zheng, L., …Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1):220-226.
5. Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892. (ESI 高被引论文Biology&Biochemistry Top1%)
6. Ying, Z.*, Xin, Y., Liu, Z.,……Liu, X*. (2025). The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming. Nature Metabolism 7(5):940-951. (Nature Metabolism当期专文评述，Nature Collection“A year of stem cell and developmental biology”)
7. Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.
8. Li, W., Long, Q., Wu, H., …Liu, X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications, 13(1):7414. (Editors’ Highlights)
9. Yang, L., Ruan, Z., Lin, X., …Liu, X*. (2024). NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nature Communications, 15: 546.
10. Hao, Z., Wu, Y., Huang, Y., …Liu, X*. (2025). Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development. Nature Communications, 16(1):10324.
11. Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances, 8(15):eabk2376.
12. Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11):eaax7525.
13. Guo, J., Duan, L., He, X., …Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (封面)
14. Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.
15. Zhou, L., Bao, F., Zheng, J…Chen, G*&Liu, X*. (2025). Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer. Molecular Psychiatry 30(10):4749-4763.
16. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1):e99165 (F1000推荐)
17. Liao, R., Wu, Y., Le, Q., … Liu, X* & Li, P*. (2023). BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal, 42(21):e113448.
18. Xiang, G., Yang, L., Long, Q., …Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9):1543-1555.
19. Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (封面)
20. Wu, Y.*, Liu, Y., Huang, Y., …Liu, X*. (2025). Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells, Cell Discovery, 2026 Jan 20;12(1):7. doi: 10.1038/s41421-025-00864-3.
21. Wu, Y., Chen, K., Li L., …Liu, X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 29(11):2316-2331. (CDDpress: Readers’ Choice)
22. Xing, G., Liu, Z., Huang L., …Pei, D* Liu, X* & Chen, K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death & Differentiation, 29(5):1042-1054.
23. Lin, Y., Li, B.,…Liu, X*, Yan, C*, Ji, K*. (2025). Lactate-driven histone lactylation enhances GDF15 secretion in skeletal muscle under mtDNA mutation-induced mitochondrial stress. Science Bulletin 71(5):998-1002.
24.Xing, G., Huang Y.,Liu, W…Dong, M*, Liang, W*, Liu, X*, Chen K*. (2026) MAP2K6 directly phosphorylates Bcl2l13 to mediate mitophagy for suppressing tumorigenicity. Cell Reports, Mar 24;45(4):117177. doi: 10.1016/j.celrep.2026.117177.
25. Yao, D., Li, Y., Zeng, S., …Liu, X*. (2022). Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences, 65(2):227-235. (封面).
26. Wang, R., Bao, F., Lu, M., …Zhang, Q.*, Liu, X*. (2024). MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber's Hereditary Optic Neuropathy. Science China-Life Sciences, 67(11):2511-2519.
27. Wu, H., Li, W., Zhou Y., …Liu, X*, Long, Q*. (2026) A new role of Iridium(III) Complexes in regulating pluripotency acquisition via mitochondrial remodulation. Science China-Life Sciences, in press.
28. Bao, F., Shi, H., Gao, M.,…Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10):966.
29. Li, L., Chen, K., Wu Y.,...Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease, 8(10):e3107.
30. Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528.
31. Yang, L., Long, Q., Liu, J., ... Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598.
32. Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020). Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.
33. Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016). Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656.
34. Xiang, G., Liu, Z., Yuan, Z…. Liu, X* (2025). Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction. Stem Cell Reports 20(5):102474.
35. Bao, F., Shi, H., Long, Q., …Liu, X*. (2016). Mitochondrial membrane potential-dependent endoplasmic reticulum fragmentation is an important step in neuritic degeneration. CNS Neuroscience & Therapeutics, 22(8):648-660. (封面)
36. Yang, L., Tang, H., Lin, X....Liu, X*. (2020). OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.
37. Wu, Y., Chen, K., Liu, X., ... Liu, X*. (2015). Srebp‐1 Interacts with c‐Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92.
38. Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of mitochondrial donut formation. Biophysical Journal, 109(5):892-899.
39. Liu, W., Long, Q., Chen, K., ... Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications, 431(4), 767-771.
40. Wu, Y., Liu, Y., Hao, Z., Liu, X*. (2022). NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine, 1(3), 401-405. (Most Picked Paper Award)
41. Tang, H., Hu, Z., Yang, L., ... Liu, X*. (2022). OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation. Mitochondrial Communications, 1, 16-22
42. Qi, J., Long, Q., Yuan Y.,…&Liu, X*. (2023). Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells through modulating metabolism, Genome Instability & Disease, 4(1), 12–20.
43. Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal, 28(20), 3074-3089. (F1000推荐)
44. Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation, 18(10), 1561-1572. (F1000推荐)
45. Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular Cell, 54(5), 870-878. (co-first author)
