教育经历：

1983年 江西大学 生物学 学士

1986年 江西大学 动物学 硕士

1990年 美国Fordham University 细胞生物学 硕士

1996年 美国爱因斯坦医学院 细胞生物学 博士

工作经历：

1996-2000年 美国Memorial Sloan-Kettering Cancer Center/HHMI 博士后

2000-2002年 美国加州大学Riverside分校 Assistant Professor

2002-至今 清华大学生命科学学院教授

2018-至今 广州再生医学与健康省实验室马普组织干细胞与再生医学研究中心主任

1. 国家自然科学基金委基础科学中心项目“卵子发生和胚胎发育的调控” 项目骨干；

2. 国家自然科学基金委重点项目“HER2/EGFR信号调控TGF-b在控制细胞增殖与EMT和细胞迁移之间的功能转换及机制” 项目负责人；

3. 科技部国家重点研发计划干细胞专项“微环境与肠干细胞的相互作用及调控机制”项目负责人；

4. 国家自然科学基金委重点项目“BMP信号在Lgr5小肠干细胞命运决定中的作用及其机制” 项目负责人；

5. 国家自然科学基金委创新研究群体“早期胚胎发育过程中TGF-b与Wnt信号的调控和交互作用”项目负责人；

6. 科技部973项目“生物膜动态变化的分子机理与功能研究” 项目首席科学家。

1.Wang YL*, Song WL*, Wang JL, Wang T, Xiong XC, Qi Z, Fu W^#, Yang XR^#,  Chen YG^#.  2019  Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, In press.

2. Li YZ*, Liu Y*, Y. Jeffrey Chiang, Huang F, Li YH, Li XT,Ning YH, Zhang WH, Deng HT, Chen YG^#.  2019  DNA Damage Activates TGF-b Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TbRII.  Cell Reports, 28(3):735.

3.Ye P, Chiang YJ, Qi Z, Li Y, Wang S, Liu Y, Li X, Chen YG^#. 2018 Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death. PLoS Genetics. 14(9):e1007697.

4.Li Y, Liu Y, Liu B, Wang J, Wei S, Qi Z, Wang S, Fu W, Chen YG^#. 2018 A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance. Cell Discovery, 4:49.

5. Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG^#.  2018  HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073.

6. Liu Y, Qi Z, Li X, Du Y, Chen YG^#. 2018 Monolayer culture of intestinal epithelium sustains Lgr5+ intestinal stem cells. Cell Discovery, 4:32.

7.Qi Z*, Li Y*, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG^#.  2017  BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.  Nature Communications, 8:13824.

8.He K, Yan X, Li N, Dang S, Xu L, Zhao B, Li Z, Lv Z, Fang X^#, Zhang Y^#, Chen YG^#. 2015   Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes.  Cell Research.  25:738.

9.Zhao B*, Qi Z*, Li Y*, Wang C, Fu W and Chen YG^#.  2015  Non-muscle-myosin-II mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells via the Rac1-PAK1-Akt axis.  Nature Communications, 6:7166.

10.Ma BY*, Cao WP*, Li WX, Gao C, Qi Z, Zhao Y, Du J,  Xue H, Peng JY, Wen J,  Chen H, Ning YH,  Huang L, Zhang H, Gao X, Yu L, Chen YG^# .  2014  Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation Cell Research,  24(8):912.

11.Zuo W*, Huang F*, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG^#.   2013  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499.

12.Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG^#.   2012  PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22(10):1467.

13.Li, Z*, Fei T*, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG^#.  2012  BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171.

14.Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han J^#, Chen YG^#. 2010 Genome-wide Mapping of SMAD Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research  20(1):36.

15.Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG^#.  2010  Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.  Nature Cell Biology，12(8):781.

16.Zhang W, Jiang YX, Wang Q, Ma XY, Xiao ZY, Zuo W, Fang XH^#, Chen YG^#.  2009  Single-molecule imaging reveals TGF-β induced type II receptor dimerization. Proceedings of the National Academy of Sciences, USA  106:15679.

17.Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG^#.  2008  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588.

18.Ma J, Wang Q, Fei T, Han JD, Chen YG^#.  2007  MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987.

19.Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG^#.  2006  Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia.  Blood, 107:1951.

20.Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG^#, Meng A^#.  2004  Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114.