樊娜娜，中国科学院广州生物医药与健康研究院，副研究员。2012年毕业于中国科学技术大学，获理学博士学位。自研究生在读期间，一直从事克隆猪及基因修饰猪研究工作，在世界上首次获得了存活的iPS 克隆猪；参与完成了ZFN、TALEN、CRISPR/Cas9 技术在猪、兔基因打靶中的应用研究及RAG基因免疫缺陷猪、TYR基因敲除白化猪模型和PARK2/PINK1双基因敲除帕金森疾病模型猪等多种模型猪的建立；近年在Cell Research，Cell regeneration 等杂志发表文章13 篇，其中第一作者文章3 篇，通讯作者文章1篇，主持国家自然科学基金青年基金1项，参加国家自然科学基金、973项目、广东省科技计划等多项。
动物克隆与转基因
基因修饰人类疾病动物模型的建立
1. Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013 Jan;23(1):162-6.
2. Fan N, Lai L. Genetically modified pig models for human diseases. J Genet Genomics. 2013 Feb 20;40(2):67-73.
3. Wang Y#, Fan N#, Song J, Zhong J, Guo X, Tian W et al. Generation of knockout rabbits using transcription activator-like effector nucleases. Cell Regeneration, 2014, February, 3:3 #co-author
4. Muti-gene targeting in rabbits using the Cas9/gRNA system. Yan Q, Zhang Q, Yang H, Zou Q, Tang C, Fan N*, Lai L*, Cell Regeneration. 2014 Sep 27;3(1):12.. * co-correspondence
5. Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, Zhao Y, Zhao B, Liu Z, Lai S, Yi X, Guo L, Esteban MA, Zeng Y, Yang H, Lai L. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci. 2014 Oct 2.
6. Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA, Yang D, Yang H, Lai L. RAG1/2 knockout pigs with severe combined immunodeficiency. J Immunol. 2014 Aug 1;193(3):1496-503.
7. Huang L, Fan N, Cai J, Yang D, Zhao B, Ouyang Z, Gu W, Lai L. Establishment of a porcine Oct-4 promoter-driven EGFP reporter system for monitoring pluripotency of porcine stem cells. Cell Reprogram. 2011 Apr;13(2):93-8.
8. Xin J, Yang H, Fan N, Zhao B, Ouyang Z, Liu Z, Zhao Y, Li X, Song J, Yang Y, Zou Q, Yan Q, Zeng Y, Lai L. Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs.
PLoS One. 2013 Dec 17;8(12):e84250.
