2005.09-2009.07 安徽大学 生物工程 学士
2009.09-2015.07 中国科学院上海生物化学与细胞生物学研究所 发育生物学 博士
2015.08-2017.08 中山大学-深圳市第二人民医院 博士后
2017.08-2019.08 香港城市大学 博士后
2019.09-2022.12 广州医科大学附属广州市妇女儿童医疗中心 儿科研究所 研究主管（副研究员）
2023.02至今 中国科学院广州生物医药与健康研究院 细胞谱系与发育研究中心 副研究员
肺损伤修复过程中细胞谱系分化的作用机制研究
肿瘤发生与免疫调控作用机制的研究
1. 国家自然科学基金青年项目（2018） 项目负责人
2. 广东省科技计划项目（2017） 项目负责人
3. 中国博士后科学基金面上项目（2015） 项目负责人
4. 广州市科技计划项目（2022） 项目负责人
5. 深圳市科技计划项目（2017） 项目负责人
6. 广州医科大学科研强基项目（2023） 项目负责人
7. 广州市高层次卫生人才引进培养项目（2022） 项目负责人
1. Liang Dong, Wenwen Luo, Skaldin Maksym, Simon C. Robson, Andrey V. Zavialov. Adenosine deaminase 2 regulates the activation of the Toll-like receptor 9 in response to nucleic acids. Frontiers of Medicine 2024, DOI: 10.1007/s11684-024-1067-5
2. Wenwen Luo*, Liang Dong*, Fenghong Chen*, Wenbin Lei*, Liya He, Qing Zhou, Thierry Lamy and Andrey V. Zavialov. ELISA based assays to measure adenosine deaminases concentration in serum and saliva for the diagnosis of ADA2 deficiency and cancer. Frontiers in Immunology 2022;13:928438. (*Indicates equal contribution)
3. Liang Dong, Xiaoming Lyu, Oluwasijibomi Damola Faleti, Ming-Liang He. The special stemness functions of Tbx3 in stem cells and cancer development. Seminars in Cancer Biology, 57(2019)105–110.
4. Liang Dong, Qi Dong, Ying Chen, Yichen Li, Bao Zhang, Fanghang Zhou, Xiaoming Lyu, George G Chen, Paul Lai, Hsiang-fu Kung, Ming-Liang He. Novel HDAC5 interacting motifs of Tbx3 are essential for suppressing E-cadherin expression and promoting metastasis of hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 2018, 3, 22.
5. Liang Dong, Fan Lin, Wanjun Wu, Yuchen Liu and Weiren Huang. Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway. International Journal of Medical Sciences, 2018, 15(6): 645-652.
6. Liang Dong, Fan Lin, Wanjun Wu, Weiren Huang and Zhiming Cai. Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. Journal of Cancer, 2016, 7(14): 2132-2138.
7. Fan Lin*, Liang Dong*, Weiming Wang, Yuchen Liu, Weiren Huang and Zhiming Cai. An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell. International Journal of Biological Sciences, 2016, 12(10): 1273-1278. (*Indicates equal contribution)
8. Liang Dong, Jinhui Li, Hongling Huang, Meng-Xin Yin, Jinjin Xu, Peixue Li, Yi Lu, Wenqing Wu, Hang Yang, Yun Zhao and Lei Zhang. Growth Suppressor Lingerer Regulates bantam microRNA to Restrict Organ Size. Journal of Molecular Cell Biology, 2015, 7(5), 415–428.
9. Meng Zhang*, Liang Dong*, Shi Jiao*, Zhubing Shi*, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Wenjia Wang, Yun Zhao, Mark Greene, Lei Zhang, and Zhaocai Zhou. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure, 2013, 21(4): 680-688. (*Indicates equal contribution)
10. Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu. Serpinc1 acts as a tumor suppressor in hepatocellular carcinoma through inducing apoptosis and blocking macrophage polarization in an ubiquitin-proteasome manner. Frontiers in Oncology, 2021, 11:738607.
11. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, Yun Zhao, Lei Zhang. Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery. 2016; 2: 16006.
12. Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao, Xin-Yuan Liu, Lei Zhang. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biology. 2013; 11: e1001620.
13. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Lei Zhang. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry. 2012; 287: 5784-96.
