教育经历（从大学开始填起）：

1999.09--2003.07:  河南农业大学   动物医学系     学士

工作经历：  

2024.04--至今：中国科学院广州生物医药与健康研究院  高级实验师

2011.03--2024.03：中国科学院广州生物医药与健康研究院 助理研究员

2009.01--2011.02：厦门大学附属演武医院中心实验室     实验师

2003.07--2008.12：山东盛能奶牛高效繁育研发基地   助理实验师

1. 动物克隆及基因编辑模式动物制备

2. 显微操作技术应用

1. Yanhui Liang#,Jingke Xie#,Quanjun Zhang#,Xiaomin Wang#,Shixue Gou,Lihui Lin,Tao Chen,Weikai Ge,Zhenpeng Zhuang,Meng Lian,Fangbing Chen,Nan Li,Zhen Ouyang,Chengdan Lai,Xiaoyi Liu,Lei Li,Yinghua Ye,Han Wu,Kepin Wang*,and Liangxue Lai*. AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic Acids Research. 2022 May 20;50(9):5384–5399.

2. Quanmei Yan#, Quanjun Zhang#, Huaqiang Yang, Qingjian Zou,Chengcheng Tang,Nana Fan*,Liangxue Lai*. Generation of multi-gene knockout rabbits using the Cas9/gRNA system. Cell Regeneration. 2014 Sep 27;3(1):12.

非第一作者论文

1. Jingke Xie#,Zhenpeng Zhuang#,Shixue Gou#,Quanjun Zhang,Xia Wang,Ting Lan,Meng Lian,Nan Li,Yanhui Liang,Zhen Ouyang,Yinghua Ye,Han Wu,Liangxue Lai*,Kepin Wang* . Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription. Nucleic Acids Research. 2023 Oct 13;51(18):10075–10093.

2. Nan Li#,Shixue Gou#,Jiaowei Wang#,Quanjun Zhang,Xingyun Huang,Jingke Xie,Li Li,Qin Jin,Zhen Ouyang,Fangbing Chen, Weikai Ge,Hui Shi,Yanhui Liang,Zhenpeng Zhuang,Xiaozhu Zhao,Meng Lian,Yinghua Ye,Longquan Quan,Han Wu*,Liangxue Lai*,Kepin Wang*. CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I. Molecular Therapy.2021 Mar,3;29(3):1001-1015.

3. Zhiquan Liu # , Siyu Chen # , Huanhuan Shan , Quanjun Zhang , Mao Chen , Liangxue Lai* , Zhanjun Li* . Efficient and precise base editing in rabbits using humanAPOBEC3A-nCas9 fusions. Cell Discovery.2019 Jun 11;5:31. 

4. Yanling Zhu#,Zhishuai Zhang#,Nana Fan#,Ke Huang,Hao Li,Jiaming Gu,Quanjun Zhang,Zhen Ouyang,Tian Zhang,Jun Tang,Yanqi Zhang,Yangyang Suo,Chengdan Lai,Jiaowei Wang,Junwei Wang,Yongli Shan,Mingquan Wang,Qianyu Chen,Tiancheng Zhou,Liangxue Lai*，Guangjin Pan*. Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells. Stem Cell Reports. 2022 May 10;17(5):1059–1069.

5.  Jingke Xie#;Weikai Ge#; Nan Li#;Qishuai Liu#;Fangbing Chen;Xiaoyu Yang,Xingyun Huang;Zhen Ouyang;Quanjun Zhang;Yu Zhao;Zhaoming Liu;Shixue Gou;Han Wu;Chengdan Lai;Nana Fan;Qin Jin;Hui Shi;Yanhui Liang;Ting Lan;Longquan Quan;Xiaoping Li;Kepin Wang*;Liangxue Lai*;Efficient base editing for multiple genes/loci in pigs using base editors. Nature Communications. 2019,June,10(1):2852.

6.  Li L,Zhang Q,Yang H,Zou Q,Lai C,Zhao Ping,Luo Z,Yang J,Chen Q,Wang Y,Newsome P,Frampton J,Maxwell P. H.,Siu T,Tam S,Tse H,Qin B,Bao X,Esteban M*,and Lai L*. Fumarylacetoacetate hydrolase knockout rabbit model for hereditary tyrosinemia type 1. J Biol Chem. 2017 Mar 17;292(11):4755-4763.

7. Wei S#, Zou Q#, Lai S#, Zhang Q, Li L, Yan Q, Zhou X, Zhong H, Lai L. Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific Reports. 2016 Jan 19;6:19648.

Song J#,Zhong J#,Guo X#,Chen Y,Zou Q,Huang J,Li X,Zhang Q,Jiang Z,Tang C,Yang H,Liu T,Li P,Pei D*,Lai L*. Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs. Cell Research. 2013 Aug;23(8):1059-62.