教育经历：

2009.09 至2013.06，陇东学院，生物科学，学士

2014.09 至2016.06，兰州大学，发育生物学，硕士

2016.09 至2021.06，兰州大学，动物学，博士

工作经历：

2021.09至2024.08，中国科学院广州生物医药与健康研究院，博士后

2024.09至2024.12，中国科学院广州生物医药与健康研究院，助理研究员

2025.01至今 中国科学院广州生物医药与健康研究院，副研究员

专注于神经退行性疾病及神经系统损伤的再生医学研究，主要通过基因编辑技术改造人源诱导多能干细胞（human iPSCs, hiPSCs），开发新型治疗策略，应用于肌萎缩侧索硬化症（ALS）、帕金森病（PD）等神经退行性疾病，以及脊髓损伤和脑卒中等神经系统损伤的治疗。

1.  Jiaowei Wang^#,Wenguang Xie^#,Nan Li^#,Wenjuan Li^#,Zhishuai Zhang^#,Nana Fan,Zhen Ouyang,Yu Zhao,Chengdan Lai,Hao Li,Mengqi Chen,Longquan Quan,Yunpan Li,Yu Jiang,Wenqi Jia,Lixin Fu,Md Abdul Mazid,Yanling Zhu,Patrick H Maxwell,Guangjin Pan*,Miguel A Esteban*,Zhen Dai* and Liangxue Lai*, Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation, Cell Stem Cell,2023,30(9):1235-1245.

2.  Ting Li *,Ting Xu,Jin Zhao,Hao Gao,Wenguang Xie, Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response, Free Radical Biology and Medicine,2022,181(2022)209–220.

3.  Wenguang Xie^#,Xiao-Ting Gong^#,Xiaofeng Cheng^#,Jingjing Cao*,Jin Zhao,Hao-Li Zhang*,and Shengxiang Zhang*, LIMPID: a versatile method for visualization of brain vascular networks, Biomaterials Science,2021,9: 2658-2669.

4.  Ting Li,Jin Zhao,Wenguang Xie,Wanru Yuan,Jing Guo,Shengru Pang,Wen-Biao Gan*,Diego Gómez-Nicola* and Shengxiang Zhang*,Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage, Journal of Neuroinflammation,2021,18(1):81.

5.  Xiao-Ting Gong^#, Wenguang Xie^#,Jing-Jing Cao*,Shengxiang Zhang*,Kanyi Pu* and Hao-Li Zhang *,NIR-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging, Biomaterials Science,2020,8: 2666-2672.

6.  Na Zhang^#,Dandan Chai^#,Huifen Du,Kesheng Li*,Wenguang Xie,Xingwen Li,Rong Yang,Xiaowen Lian and Yang Xu,Expression of Reg IV and SOX9 and their correlation in human gastric cancer,BMC Cancer,2018,18:344.

7.  Zhijie Yang,Wenguang Xie,Furong Ju,Akbar khan,Shengxiang Zhang*,In vivo two-photon imaging reveals a role of progesterone in reducing axonal dieback after spinal cord injury in mice, Neuropharmacology,2016,116(116):30-37.