2004/9-2008/6， 湖南师范大学，生物基地，学士

2008/9-2011/6， 华南理工大学，发酵工程，硕士

2011/8-2012/8，中国科学院广州生物医药与健康研究院，研究实习员

2012/9-2015/6， 中国科学院大学，生物化学与分子生物学，博士

2015/7-至今，中国科学院广州生物医药与健康研究院，助理研究员，副研究员

1. 线粒体DNA在发育、衰老和疾病中的作用机制；

2. 线粒体生物学。

1. 国家重点研发计划“干细胞及转化研究”重点专项（2017，学术骨干） 

2. 广东省自然科学基金面上项目（2021，项目负责人）

3. 广东省自然科学基金自由申请（2018，项目负责人）

4. 广东省省级科技计划项目（2017，项目负责人）

5. 广州市科技计划项目基础研究计划（2021，项目负责人）

6. 广州市科技计划项目一般项目（2017，项目负责人）

7. 基因功能与调控教育部重点实验室开放研究基金课题（2018，项目负责人）

1. 第一届全国博士后创新创业大赛银奖（2021，项目负责人）

2. 广东省科学技术奖自然科学一等奖（2020，6/15）

3. 冷泉港亚洲线粒体会议并列第一名（共二人，2015）。

4. 第12届亚洲线粒体生物医学及研究学会国际会议暨第六届中国线粒体学会学术会议海报奖（2015）

1. Hu Z#, Yang L#, Zhang M#, Tang H, Huang Y, Su Y, Ding Y, Li C, Wang M, Zhou Y, Zhang Q, Guo L, Wu Y, Wang Q, Liu N, Kang H, Wu Y, Yao D, Li Y, Ruan Z, Wang H, Bao F, Liu G, Wang J, Wang Y, Wang W, Lu G, Qin D, Pei D, Chan W, Liu X*. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. [J] Cell Metabolism, 2024, 36:1-36 (#，共同第一作者)
2. Yang L#, Ruan Z#, Lin X #, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes K, Chan W, Liu X*. NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. [J]Nature Communications, 2024, 15(1):546 
3. Yang L#, Lin X #, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X*. Mitochondrial DNA mutation exacerbates female reproductive ageing via impairment of the NADH/NAD+ redox. [J] Aging cell. 2020, 19(9):e13206
4. Yang L#, Long Q, Liu J, Tang H, Li Y, Bao F, Qin D, Pei D, Liu X*. Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA. [J] Cell Mol Life Sci. 2015, 72(13):2585-98
5. Yang L#, Tang H#, Lin X, Wu Y, Zeng S, Pan Y, Li Y, Xiang G, Lin Y, Zhuang S, Song Z, Jiang Y, Liu X*. OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. [J] Front Cell Dev Biol, 2020，8:180
6. Yang L#, Mei T, Lin X, Tang H, Wu Y, Wang R, Liu J, Shah Z, Liu X*. (2016). Current approaches to reduce or eliminate mitochondrial DNA mutations.[J] Sci China Life Sci. 2016, 59(5):532-5
7. ……Yang L#……  ……Liu X*……. Biomarkers of Aging. Sci China Life Sci. 2023. 66(5):893-1066.  (共一，按姓氏排名)
8. Hong WX#, Yang L#, Chen M#, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J*. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells. [J] Toxicol Appl Pharmacol. 2012, 263(2):259-72 
9. Tang H#, Hu Z#, Yang L#, Ruan Z, Wang H, Zhou Y, Bao F, Liu X*. OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation. Mitochondrial Communications. 2023.1:16-22.
10. Xiang G, Yang L, Long Q, Chen K, Tang H, Wu Y, Liu Z, Zhou Y, Qi J, Zheng L, Liu W, Ying Z, Fan W, Shi H, Li H, Lin X, Gao M, Liu J, Bao F, Li L, Duan L, Li M, Liu X*. BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming. Autophagy. 2017, 13(9):1543-1555. 
11. Liu X*, Yang L, Long Q, Weaver D, Hajnoczky G*.Choosing proper fluorescent dyes, imaging techniques to study mitochondrial dynamics in mammalian cells. Biophys Rep. 2017, 3 (4-6): 64-72.  
12. Ying Z，Chen K，Zheng L，Wu Y，Li L，Wang R，Long Q，Yang L，Guo J，Yao D，Li Y，Bao F，Xiang G，Liu J，Huang Q，Wu Z，Hutchins AP，Pei D，Liu X*. Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. [J] Cell Metabolism. 2016, 23(1):220-226.
13. Ying Z, Xiang G, Zheng L, Tang H, Duan L, Lin X, Zhao Q, Chen K, Wu Y, Xing G, Lv Y, Li L, Yang L, Bao F, Long Q, Zhou Y, He X, Wang Y, Gao M, Pei D, Chan WY, Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 2018, 28(6):935-945. 
14. Li S, Guo J, Ying Z, Chen S, Yang L, Chen K, Long Q, Qin D, Pei D, Liu X*.Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mPTP opening dependent apoptotic sensitivity in an iPSC model. [J] Hepatology. 2015, 61(5):1730-9. 
15. Zhou Y, Long Q, Wu H, Li W, Qi J, Wu Y, Xiang G, Tang H, Yang L, Chen K, Li L, Bao F, Li H, Wang Y, Li M, Liu X*, Topology-dependent, bifurcated mitochondrial quality control under starvation. [J] Autophagy. 2019, 4:1-13. 
16. Guo J, Duan L, He X, Li S, Wu Y,  Xiang G, Bao F, Yang L, Shi H, Gao M, Zheng L, Hu H,  Liu X*.A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. [J] Advanced Science. 2021, 2004680
17. Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan W, Liu J, Chen Y, Li P, Liu X*. Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Struc & Mol Biology. 2021. 28(11):900-908.
18. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M,*, Liu X* Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances.2022, 8:eabk2376.
19. Yao D, Li Y, Zeng S, Li Z, Shah Z, Song Z, Liu J, Wu Y, Yang L, Long Q, Wang W, Hu Z, Tang H, Liu X*.  Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space. Sci China Life Sci. 2022, 65(2):227-235
20. Lin YF, Xiao MH, Chen HX, Meng Y, Zhao N, Yang L, Tang H, Wang JL, Liu X*, Zhu Y*, Zhuang SM*. A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. [J]. Cell Death Dis. 2019, 10(7):528. 
21. Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, Wu Y, Chen K, Xiang G, Long Q Guo J, Zhang J, Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death Dis, 2018, 9(10):966. 
22. Bao F, Shi H, Long Q, Yang L, Wu Y, Ying Z, Qin D, Zhang J, Guo Y, Li H, Liu X*. Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. [J] CNS Neurosci Ther. 2016, 22(8):648-60.
23. Long Q, Zhao D, Fan W, Yang L, Zhou Y, Qi J, Wang X*, Liu X*. Modeling of Mitochondrial Donut Formation. [J] Biophysical Journal. 2015, 109(5): 892-899.

授权专利

1. 刘兴国，杨亮，林晓冰，唐海特，检测mtDNA突变的方法和系统，2022-05-06，中国，CN111621552B，201910509687.4
2. 刘兴国，杨亮，唐海特，Opa1 异形体蛋白在调控肝癌细胞增殖能力中的用途，2022-06-06，中国，CN111518898A，201910105768.8