2007年09月-2011年07月 安徽大学生命科学学院 生物工程 工学学士

2011年09月-2016年07月 中国科学院广州生物医药与健康研究院 发育生物学 理学博士

2016年07月-2017年12月 中国科学院广州生物医药与健康研究院 助理研究员

2018年01月-2018年06月 中国科学院广州生物医药与健康研究院 副研究员（试聘）

2018年07月-2022年12月 中国科学院广州生物医药与健康研究院 副研究员

2022年12月-至今 中国科学院广州生物医药与健康研究院 研究员

基因修饰大动物模型构建与应用；

新型基因编辑技术开发与优化。

1. 国家自然科学基金面上项目（2022.01-2025.12），项目负责人；

2. 国家重点研发计划项目（2021.12-2026.11），子课题负责人；

3. 国家自然科学基金专项项目（2020.01-2022.12），项目负责人；

4. 国家自然科学基金青年科学基金项目（2018.01-2020.12），项目负责人；

5. 海南省重点研发计划项目（2021.09-2023.09），项目负责人；

6. 中国科学院战略生物资源能力建设项目（2020.01-2021.12），项目负责人。

广东省遗传学会理事、副秘书长；

中国科学院青年创新促进会广州分会第三届、第四届委员会委员。

中国科协青年人才托举工程项目入选者；

中国科学院青年创新促进会会员。

1.       Qin Jin^#, Xiaoyi Liu^#, Zhenpeng Zhuang^#, Jiayuan Huang^#, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang*, Liangxue Lai*, Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Genome Biology, 2023, 24:8.

2.       Xunlei Wang^#, Qin Jin^#, Wenwen Xiao^#, Puxian Fang, Liangxue Lai, Shaobo Xiao, Kepin Wang*, Liurong Fang*, Genome-wide CRISPR/Cas9 screen reveals a role for SLC35A1 in the adsorption of porcine deltacoronavirus, Journal of Virology, 2022, 96(24):e0162622.

3.       Qin Jin^#, Xiaoyu Yang, Shixue Gou, Xiaoyi Liu, Zhenpeng Zhuang, Yanhui Liang, Hui Shi, Jiayuan Huang, Han Wu, Yu Zhao, Zhen Ouyang, Quanjun Zhang, Zhaoming Liu, Fangbing Chen, Weikai Ge, Jingke Xie, Nan Li, Chengdan Lai, Xiaozhu Zhao, Jiaowei Wang, Meng Lian, Lei Li, Longquan Quan, Yinghua Ye, Liangxue Lai*, Kepin Wang*, Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Science China Life Sciences, 2022, 65(11):2269-2286.

4.       Yanhui Liang^#, Jingke Xie^#, Quanjun Zhang^#, Xiaomin Wang^#, Shixue Gou, Lihui Lin, Tao Chen, Weikai Ge, Zhenpeng Zhuang, Meng Lian, Fangbing Chen, Nan Li, Zhen Ouyang, Chengdan Lai, Xiaoyi Liu, Lei Li, Yinghua Ye, Han Wu, Kepin Wang*, Liangxue Lai*, AGBE: A dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Nucleic Acids Research, 2022, 50(9):5384-5399.

5.       Nan Li^#, Shixue Gou^#, Jiaowei Wang^#, Quanjun Zhang, Xingyun Huang, Jingke Xie, Li Li, Qin Jin, Zhen Ouyang, Fangbing Chen, Weikai Ge, Hui Shi, Yanhui Liang, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Yinghua Ye, Longquan Quan, Han Wu*, Liangxue Lai*, Kepin Wang*, CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I, Molecular Therapy, 2021, 29(3):1001-1015.

6.       Meng Lian^#, Fangbing Chen^#, Xingyun Huang^#, Xiaozhu Zhao, Shixue Gou, Nan Li, Qin Jin, Hui Shi, Yanhui Liang, Jingke Xie, Weikai Ge, Zhenpeng Zhuang, Jiaowei Wang, Yinghua Ye, Yi Yang, Kepin Wang*, Liangxue Lai*, Han Wu*, Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, Journal of Genetics and Genomics, 2021, 48(1):92-95.

7.       Wenjing Li^#, Lei Shi^#, Zhenpeng Zhuang^#, Han Wu^#, Meng Lian, Yihui Chen, Lei Li, Weikai Ge, Qin Jin, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Zhen Ouyang, Yinghua Ye, Yingying Li, Hai Wang, Yuan Liao, Longquan Quan, Lei Xiao, Liangxue Lai*, Guangxun Meng*, Kepin Wang*, Engineered pigs carrying a gain-of-function NLRP3 homozygous mutation can survive to adult and accurately recapitulate human systemic spontaneous inflammatory responses, Journal of Immunology, 2020, 205(9):2532-2544.

8.       Jingke Xie^#, Xingyun Huang^#, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang*, Liangxue Lai*, ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, BMC Biology, 2020, 18:131.

9.       Jingke Xie^#, Weikai Ge^#, Nan Li^#, Qishuai Liu^#, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang*, Liangxue Lai*, Efficient base editing for multiple genes/loci in pigs using base editors, Nature Communications, 2019, 10:2852.

10.    Han Wu^#, Qishuai Liu^#, Hui Shi, Jingke Xie, Quanjun Zhang, Zhen Ouyang, Nan Li, Yi Yang, Zhaoming Liu, Yu Zhao, Chengdan Lai, Degong Ruan, Jiangyun Peng, Weikai Ge, Fangbing Chen, Nana Fan, Qin Jin, Yanhui Liang, Ting Lan, Xiaoyu Yang, Xiaoshan Wang, Zhiyong Lei, Pieter A. Doevendans, Joost P. G. Sluijter, Kepin Wang*, Xiaoping Li*, Liangxue Lai*, Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems, Cellular and Molecular Life Sciences, 2018, 75(19):3593-3607.

11.    Degong Ruan^#, Jiangyun Peng^#, Xiaoshan Wang^#, Zhen Ouyang^#, Yi Yang, Fangbing Chen, Weikai Ge, Han Wu, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Chengdan Lai, Nana Fan, Zhiwei Zhou, Qishuai Liu, Nan Li, Qin Jin, Hui Shi, Jingke Xie, Xiaoyu Yang, Hong Song, Kepin Wang*, Xiaoping Li*, Liangxue Lai*, Xist derepression in active X chromosome hinders pig somatic cell nuclear transfer, Stem Cell Reports, 2018, 10(2): 494-508.

12.    Kepin Wang^#, Qin Jin^#, Degong Ruan^#, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li*, Liangxue Lai*, Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Genome Research, 2017, 27(12): 2061-2071.

13. Yi Yang^#, Kepin Wang^#, Han Wu, Qin Jin, Degong Ruan, Zhen Ouyang, Bentian Zhao, Zhaoming Liu, Yu Zhao, Quanjun Zhang, Nana Fan, Qishuai Liu, Shimei Guo, Lei Bu, Yong Fan, Xiaofang Sun, Xiaoping Li*, Liangxue Lai*, Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, Journal of Molecular Cell Biology, 2016, 8(2): 174-177.