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专家人才

  • 姓名： 郭文静
  • 性别： 女
  • 职称： 高级工程师
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: guo_wenjing@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 2006.09－2008.07：唐山师范学院，生命科学，学士

    2008.09－2011.07：华南师范大学，生物物理，硕士

    2011.08－2016.03：香港大学，生物医学科学，博士

    2016.04－2016.04：香港大学，生物医药科学学院，助理研究员

    2016.05－2019.04：中国科学院广州生物医药与健康研究院，工程师

    2019.05－至  今：中国科学院广州生物医药与健康研究院，高级工程师

    研究领域：

  • 1.通过光学显微成像技术探究与自噬相关的分子作用机理

    2. 自噬对动脉粥样硬化发生和发展过程的调控

    承担科研项目情况：

  • 中国科学院仪器设备功能开发技术创新项目，项目负责人

    社会任职：

    获奖及荣誉：

    代表论著：

  • 第一作者论文：

    1. Guo W, Wang Q, Pan S, Li J, Wang Y, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J. The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. J Cell Physiol. 2021 Mar 8. doi: 10.1002/jcp.30354.

    2. Xu X*, Guo W*, Pan S, Zhang Y, Gao F, Wang J, Zhang S, Li H, Wang R, Zhang X. TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer. Aging (Albany NY). 2020 Oct 8;12(19):19335-19351. (*共同第一作者)

    3. Guo W, Hao B, Wang Q, Lu Y, Yue J. Requirement of B-Raf, C-Raf, and A-Raf for the growth and survival of mouse embryonic stem cells. Exp Cell Res. 2013 Nov 1;319(18):2801-11.

    4. Guo W, Qian L, Zhang J, Zhang W, Morrison A, Hayes P, Wilson S, Chen T, Zhao J. Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. J Neurosci Res. 2011 Nov;89(11):1723-36.

    5. Guo W, Chen T, Wang X, Chen R. Taxol induces concentration-dependent apoptotic and paraptosis-like cell death in human lung adenocarcinoma (ASTC-a-1) cells. J Xray Sci Technol. 2010;18(3):293-308.

     

    共同作者论文：

    1. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy. 2016 Aug 2;12(8):1340-54.

    2. Qi X, Liu H, Guo W, Lin W, Lin B, & Jin Y, et al. (2019). New opportunities: second harmonic generation of boron‐doped graphene quantum dots for stem cells imaging and ultraprecise tracking in wound healing. Advanced Functional Materials, 29(37), 1902235.1-1902235.10.

    3. Lin W, Qi X, Guo W, Liang D, Chen H, Lin B, Deng X. A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing. Stem Cell Res Ther. 2020 Sep 7;11(1):383.

    4. Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D. SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021 Jul 2;12(1):4090.

    5. Xu Y, Zhou J, Liu C, Zhang S, Gao F, Guo W, Sun X, Zhang C, Li H, Rao Z, Qiu S, Zhu Q, Liu X, Guo X, Shao Z, Bai Y, Zhang X, Quan D. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials. 2021 Jan;268:120596.

    6. Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G, Yao H. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Prolif. 2021 May;54(5):e13000.

    7. Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen YS, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang YG, Yao H. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nat Commun. 2019 Apr 4;10(1):1535.

    8. Yang X, Wang Q, Hu P, Xu C, Guo W, Wang Z, Mao Z, Yang Z, Liu C, Shi G, Chen L, Xu B and Chi Z. Achieving remarkable and reversible mechanochromism from a bright ionic AIEgen with high specificity for mitochondrial imaging and secondary aggregation emission enhancement for long-term tracking of tumors. Mater. Chem. Front., 2020, 4, 941.

    9. Yu L, Liu X, Ye X, Su W, Zhang X, Deng W, Luo J, Xiang M, Guo W, Zhang S, Xu W, Yan Q, Wang Q, Cui Y, Wu C, Guo W, Niu X, Zhang F, Lei C, Qu L, Chen L, Feng L. Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fcγ Receptor-Dependent and -Independent Pathways. mBio. 2021 Feb 9;12(1):e03179-20.

    10. Wang L, Xu X, Jiang C, Ma G, Huang Y, Zhang H, Lai Y, Wang M, Ahmed T, Lin R, Guo W, Luo Z, Li W, Zhang M, Ward C, Qian M, Liu B, Esteban MA, Qin B. mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. FEBS J. 2020 Jan;287(1):108-121.

    11. Chen M, Shi H, Gou S, Wang X, Li L, Jin Q, Wu H, Zhang H, Li Y, Wang L, Li H, Lin J, Guo W, Jiang Z, Yang X, Xu A, Zhu Y, Zhang C, Lai L, Li X. In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers. Genome Med. 2021 Apr 12;13(1):57.

    12. Wang Q, Xiong Y, Zhang S, Sui Y, Yu C, Liu P, Li H, Guo W, Gao Y, Przepiorski A, Davidson AJ, Guo M, Zhang X. The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics Approach. Front Genet. 2021 Feb 10;12:632810.

    13. Xing Q, Lin A, Su Z, Liu C, Huang W, Guo W, Pan G, Guo Y, Zhong X. Retrograde monosynaptic tracing through an engineered human embryonic stem cell line reveals synaptic inputs from host neurons to grafted cells. Cell Regen. 2019 Mar 1;8(1):1-8.

    14. Zhang S, Yi C, Li C, Zhang F, Peng J, Wang Q, Liu X, Ye X, Li P, Wu M, Yan Q, Guo W, Niu X, Feng L, Pan W, Chen L, Qu L. Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. Antiviral Res. 2019 Sep;169:104547.