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专家人才

  • 姓名： 张颖
  • 性别： 男
  • 职称： 正高级工程师
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: 
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 中国科学技术大学学士、康奈尔大学博士，中盛溯源生物科技有限公司联合创始人、首席技术官（CTO）。主要研究内容：利用重编程、定向分化、和基因修饰等技术。开发hiPSC来源细胞药物开发，参与承接科技部十三五和十四五国家重点研发计划《干细胞制剂及应用的标准化研究》和《干细胞及相关产品质量控制及评价技术》，建立中国人群“超级供体”hiPSC库、参与起草国内首个《人诱导多能干细胞》标准、完成临床级hiPSC建库质量复核。2022年9月首个iPSC来源间充质样细胞治疗产品“NCR100注射液”获得国家药品监督管理局药品审评中心的临床试验默示许可。

    研究领域：

  • 1． hiPSC向体节中胚层细胞分化，开发iMSC等细胞治疗产品；

    2． hiPSC向血液谱系分化，开发iNK等肿瘤免疫治疗产品；

    3． hiPSC向特定神经祖细胞分化，开发面向帕金森等神经退行性疾病的细胞治疗产品。

    承担科研项目情况：

    社会任职：

    获奖及荣誉：

    代表论著：

  • 发表论文和专利

    1. Zhang H, Su B, Jiao L, Xu ZH, Zhang CJ, Nie J, Gao ML, Zhang YV#, Jin ZB#. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China. Ann Transl Med. 2021 Feb;9(3):245. (#Corresponding)

    2. Yu J, Zhao T, Ma A, Zhang Y, Zhang K, Cheng L, Deng H, Kang J, Jin Z, Pan G, Hao J, Zhang Y, Fu B, Hu S, Na J, Liu Y, Cao J, Wang L, Zhu H. 《人诱导多能干细胞团体标准》，中国细胞生物学会，2021 Jan.

    3. 一种中脑多巴胺能神经前体细胞及其制备方法和应用, 专利申请号201910169525.0

    4. 视网膜色素上皮细胞及其制备方法和应用，专利申请号201910320076.5.

    5. 一种肾上皮细胞及其制备方法和应用，专利申请号201910834502.7.

    6. 一种间充质干细胞及其制备方法和应用，专利号ZL201910884482.4.

    7. 一种微环游离型载体高效重编程血液细胞生成iPSC的方法, 专利号ZL201810252408.6

    8. 一种通过蝾螈Oct4将人类血液细胞重编程为iPSC的方法, 专利号ZL201810137319.7 9. Wang AB, Zhang YV, and Tumbar T. (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 2017 Jan 4;36(1):61-78.

    10. Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang YV, and Tumbar T. (2016) Signaling couples hair follicle stem cell quiescence with reduced H3K4/K9/K27me3 levels for proper tissue homeostasis. Nature Communications 2016 Apr 15;7:11278

    11. Zhang YV, Johns L., Yu J. (2014) Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures. US Patent CDIN.P0055US.P1.

    12. Zhang YV, White B.S., Shalloway D.I., Tumbar T. (2010) Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing. Cell Cycle 2010 Apr 19;9(8).

    13. Zhang YV, Cheong J., Ciapurin N., McDermitt D.J., Tumbar T. (2009) Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell, Volume 5, Issue 3, 267-278.

    14. Waghmare S.K., Bansal R., Lee J.*, Zhang YV*, McDermitt D.J., Tumbar T. (2008) Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J. 27(9):1309-20. (* equal contribution)

    15. Osorio, K.M., Lee, S.E., McDermitt, D.J., Waghmare, S.K., Zhang, YV, Woo, H.N. Tumbar, T. (2008) Acute Myeloid Leukemia Factor 1 Controls Developmental but not Injury Driven Activation of Hair Follicle Stem Cells. Development, 135, 1059-1068.

    16. Yao X., Zhang Y., Chen W., Dou Z. (2005) Patent: A new developed absorbent polymer for protein condensation. The State Intellectual Property Office of the People's Republic of China Patent No.: ZL200310106547.1

    17. Dou Z., Ding X., Zereshki A., Zhang Y., Zhang J., Wang F., Sun J., Huang H., Yao X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572: 51–56.