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专家人才

  • 姓名： 陈奇
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: chen_qi@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 2003-2007 华东理工大学 学士

    2007-2013 中国科学院上海生命科学研究院 博士

    2013-2021 德国马普分子生物医学研究所及明斯特大学医学院 博士后

    研究领域：

  • 1、造血干细胞与骨髓微环境相互作用

    2、血管在呼吸疾病与再生中的功能

    承担科研项目情况：

    社会任职：

    获奖及荣誉：

  • 1、2019年 马普分子生物医学所突出工作奖

    2、2019年 德国干细胞协会年会墙报奖

    3、2016年 Gordon Research Conference旅行奖

    4、2011年 第七届欧洲斑马鱼会议墙报奖

     

    国际学术大会口头报告

    1、2018年 Gordon Research Conference, Endothelial cell phenotypes in health and disease

    2、2018年 EMBL Conference, Hematopoietic stem cells from the embryo to the aging organism

    3、2015年 Dutch German joint meeting of the Molecular Cardiology

    4、2012年 Kloster Seeon Angiogenesis meeting

     

     

    代表论著：

  • （1）Qi Chen#, Yang Liu#, Hyun-Woo Jeong, Martin Stehling, Van Vuong Dinh, Bin Zhou, Ralf H. Adams. Apelin+ endothelial niche cells control hematopoiesis and mediate vascular regeneration after myeloablative injury. Cell Stem Cell, 2019 Dec 5;25(6):768-783.e6. doi: 10.1016/j.stem.2019.10.006. #Equal contribution （影响因子：24.633）

    Cell Stem Cell专门评论文章: Mutualism in the Marrow 2019 Dec 5;25(6):731-733. doi: 10.1016/j.stem.2019.11.007.

    （2）Yang Liu#, Qi Chen#, Hyun-Woo Jeong, Dong Han, J？rg Fabian, Hannes Drexler, Martin Stehling, Hans R. Sch？ler, Ralf H. Adams. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood, 2021 Nov 25;138(21):2051-2065. doi: 10.1182/blood.2020010419. （封面文章, Featured Article）# Equal contribution  (影响因子: 23.629)

    Blood专门评论文章: Dopamine motivates stem cells for reward. Blood. 2021 Nov 25;138(21):2012-2014. doi: 10.1182/blood.2021013538 

    （3）Yang Liu#, Qi Chen#, Hyun-Woo Jeong#, Bong-Ihn Koh, Emma Watson, Cong Xu, Martin Stehling, Bin Zhou, Ralf H. Adams. A specialized bone marrow microenvironment for fetal haematopoiesis. Nature Communications, 2022, 13 (1327). https://doi.org/10.1038/s41467-022-28775-x  (影响因子: 14.919)

    （4）Qi Chen, Hui Zhang, Yang Liu, Dagmar Zeuschner, Monica Corada, Elisabetta Dejana, Bin Zhou and Ralf H. Adams. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. (2016) Nature Communications. 7:12422 doi: 10.1038/ncomms12422. (影响因子: 14.919，已被引123次) 

    （5）Qi Chen#, Luan Jiang#, Chun Li, Dan Hu, Ji-wen Bu, David Cai, Jiu-lin Du.  Haemodynamics- Driven Developmental Pruning of Brain Vasculature in Zebrafish. (2012) PLoS Biology 10(8): e1001374. #Equal contribution (已被引125次)

    被Nature选为亮点论文：Highlight in Neurodevelopment: Low flow blood vessel pruning. Nature (2012) 488(7413): 560.

    PLoS Biology专门评论文章 (2012) Pruning Brain Vasculature for Efficiency. PLoS Biol 10(8): e1001375

    （6）David Rohde, Katrien Vandoorne, I-Hsiu Lee, Jana Grune, Shuang Zhang, Cameron S. McAlpine, Maximilian J. Schloss, Ribhu Nayar, Gabriel Courties, Vanessa Frodermann, Gregory Wojtkiewicz, Lisa Honold, Qi Chen, Stephen Schmidt, Yoshiko Iwamoto, Yuan Sun, Sebastian Cremer, Friedrich F. Hoyer, Oriol Iborra-Egea, Christian Mu？oz-Guijosa, Fei Ji, Bin Zhou, Ralf H. Adams, Joshua D. Wythe, Juan Hidalgo, Hideto Watanabe, Yookyung Jung, Anja M. van der Laan, Jan J. Piek, Youmna Kfoury, Pauline A. Désogère, Claudio Vinegoni, Partha Dutta, Ruslan I. Sadreyev, Peter Caravan, Antoni Bayes-Genis, Peter Libby, David T. Scadden, Charles P. Lin, Kamila Naxerova, Filip K. Swirski & Matthias Nahrendorf. Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nature Cardiovascular Research 2022, 1(28–44) （创刊号论文）

            Nature 专门评论文章: Cardiovascular diseases disrupt the bone-marrow niche. https://doi.org/10.1038/d41586-021-03550-y

            Nature Reviews Cardiology专门评论文章: Cardiovascular disease alters the bone marrow vasculature https://doi.org/10.1038/s41569-022-00671-3

    （7）Cong Xu, Van Vuong Dinh, Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara Elena Pitulescu, Ralf H Adams. Induction of osteogenesis by bone-targeted Notch activation. eLife, 2022, Feb 4;11:e60183. doi: 10.7554/eLife.60183.

    （8）Ting-ting Liu, Xu-fei Du, Bai-bing Zhang, Hua-xing Zi, Yong Yan, Jiang-an Yin, Han Hou, Shan- ye Gu, Qi Chen, Jiu-Lin Du. Piezo1-mediated Ca2+ activities regulate brain vascular pathfinding during development. (2020) Neuron doi.org/10.1016/j.neuron.2020.07.025 (影响因子: 17.173)

    （9）Yang Liu, Xiao-Hui Xu, Qi Chen, Tong Wang, Cai-Yun Deng, Bao-Liang Song, Jiu-Lin Du, Zhen- Ge Luo. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. (2013) Nature Communications. doi:10.1038/ncomms3005  (影响因子: 14.919)

    （10）Yu Zhang, Bing Xu, Qi Chen, Yong Yan, Jiu-lin Du, Xufei Du. Apoptosis of Endothelial Cells Contributes to Brain Vessel Pruning of Zebrafish During Development. (2018) Front. Mol. Neurosci. 11:222. doi: 10.3389/fnmol.2018.00222 (影响因子: 5.639)