自2016年在Science, Nature Communications, Hepatology, Clinical Cancer Research等杂志发表多篇研究论文,包括一篇ESI高被引论文。围绕疾病和器官再生相关的表观调控组学,主要开发了组学整合、调控网络重构等新方法,揭示了神经退化和再生修复的表观调控图谱,并部分实现了哺乳动物的视网膜再生。(#共同第一作者,*共同通讯作者)
1. Hoang T#,Wang J#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T,Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR*, Qian J*, Blackshaw S*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 370, 934 (2020).
2. Wang J#, Zibetti C#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S*, Qian J*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications 9, 1364 (2018).
3. Yuan S#, Wang J#*, Yang Y, Zhang J, Liu H, Xiao J, Xu Q, Huang X, Xiang B, Zhu S, Li L*, Liu J*, Liu L*, Zhou W*. The prediction of clinical outcome in hepatocellular carcinoma based on a six-gene metastasis signature. Clinical Cancer Research 23, 289-97 (2017).
4. Yuan S#, Wang J#, Yang F#, Tao Q#, Wang L, Yang Y, Zheng H, Wang Z, Xu Q, Wang F, Liu L*, Sun S* and Zhou W*. Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. Hepatology 63, 499-511 (2016). ESI Highly Cited Paper (> 200 citations).
5. Jiang J#, Lyu P#, Li J#, Huang S, Tao J, Blackshaw S, Qian J, Wang J*. IReNA: integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience 25, 105359 (2022).