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专家人才

  • 姓名： 熊晓犁
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: xiong_xiaoli@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 熊晓犁，博士，研究员，广东省珠江人才计划青年拔尖人才，英国微生物学会会员。在英国布里斯托大学生物化学系/细胞和分子医学系分别获得生物化学与生物技术学士学位和病理学与微生物学博士学位。熊晓犁研究员先后在英国MRC National Institute for Medical Research (现Francis Crick Institute) 病毒学系 Sir John Skehel研究组，美国华盛顿大学（西雅图）生物化学系，英国MRC Laboratory of Molecular Biology结构生物学系从事病原微生物致病机理的研究。2020年9月加入中国科学院广州生物医药与健康研究院。

     

    近10年来熊晓犁研究员研究了H5N1, H7N9, H10N8流感病毒的跨种传播机理（Xiong et. al. Nature 2013a, Xiong et. al. Nature 2013b, Xiong et. al. Virology 2014, Vachieri*, Xiong.* et. al.  Nature 2014）, 流感病毒的装配机制 （Peukes*, Xiong*# et. al. Nature 2020）。冠状病毒的入侵机制 (Xiong et. al. J. Virology 2018, Walls*, Xiong* et. al. Cell 2019), 新型冠状病毒表面抗原S蛋白的稳定化（Xiong*# et. al.  Nat. Struct. Mol. Biol. 2020）等科学问题。研究团队旨在运用结构生物学与生物化学方法探明病原微生物的致病机理，并在理解其致病机理的基础上开发干预手段。

    研究领域：

    承担科研项目情况：

    社会任职：

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    获奖及荣誉：

    代表论著：

  • 1.      Xiong, X.*#, Qu, K.*, Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., The CITIID-NIHR COVID-19 Bioresource, Nathan, J.A., Baker, S., James, L.C., Helen, E., Goodfellow, I., Doffinger, R., and Briggs, J.A.G. # (2020). A thermostable, closed, SARS-CoV-2 spike protein trimer. Nat. Struct. Mol. Biol.

     

    2.      Peukes, J.*, Xiong, X.*#, Erlendsson, S., Qu, K., Wan, W., Leslie, J., Schraidt, O., Kummer, S., Freund, S.M.V., Kraeusslich H-G., Briggs, J.A.G #. (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature.

     

    3.      Zunlong Ke, Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt2, C.J., Lu, J.M., Peukes, J., Xiong, X., Kraeusslich, H-G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions. Nature.

     

    4.      Mlcochova, P., Collier, D., Ritchie, A. V, Assennato, S.M., Hosmillo, M., Goel, N., Meng, B., Chatterji, K., Mendoza, V., Temperton, N., Kiss, L., Ciazyns, K.A., Xiong, X., Briggs, J.A.G., Nathan, J., Mescia, F., Zhang, H., Barmpounakis, P., Demeris, N., et al. (2020). Combined point of care SARS-CoV-2 nucleic acid and antibody testing in suspected moderate to severe COVID-19 disease. Cell Reports Medicine.

     

    5.      Zheng, A., Sun, W., Xiong, X., Freyn, A.W., Peukes, J., Stromeier, S., Nachbagauer, R., Briggs, J.A.G., Krammer, F., and Palese, P. (2020). Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. J. Virol. .

     

    6.      Gamblin, S.J., Vachieri, S.G., Xiong, X., Zhang, J., Martin, S.R., and Skehel, J.J. (2020). Hemagglutinin Structure and Activities. Cold Spring Harb. Perspect. Med. a038638.

     

    7.      Walls, A. C.*, Xiong, X.*, Park, Y, Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Dai, M., Zambon, M., Rey, F. A., Corti, D., Veesler, D. (2019). Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Cell 176,1026-1039

     

    8.      Xiong, X.,Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B., Veesler, D., (2018) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. J. Virology, 92, e01628-17

     

    9.      Walls, A. C, Tortorici, M. A, Snijder, J, Xiong, X, Bosch, B. J, Rey, F. A and Veesler, D., (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Natl Acad Sci. U S A 114:11157-11162.

     

    10.   Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S. R., Lin, Y.P., Walker, P. A., Collins, P. J., Moine, I., Suguitan Jr., A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J. J., (2015) Structures of complexes formed by H5 influenza haemagglutinin with a potent broadly neutralizing human monoclonal antibody. Proc Natl Acad Sci U S A 112, 9430-9435.

     

    11.   Xiong, X. McCauley, J.W., Steinhauer, D.A. (2014). Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range. Curr Top Microbiol Immunol 385, 63-91

     

    12.   Vachieri, S.G.*, Xiong, X.*, Collins, P.J., Walker, P.A., Martin, S.R., Haire, L.F., Zhang, Y., McCauley, J.W., Gamblin, S.J., and Skehel, J.J. (2014). Receptor binding by H10 influenza viruses. Nature 511, 475-477.

     

    13.   Xiong, X.*, Xiao, H.*, Martin, S. R., Coombs, P. J., Liu, J., Collins, P. J., Vachieri, S. G., Walker, P. A., Lin, Y. P., McCauley, J. W., Gamblin, S. J. & Skehel, J. J. (2014). Enhanced human receptor binding by H5 haemagglutinins. Virology, 456-457, 179-187.

     

    14.   Xiong, X., Tuzikov, A., Coombs, P. J., Martin, S., Walker, P. A., Gamblin, S. J., Bovin, N. & Skehel, J. J. (2013). Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res, 178, 12-4.

     

    15.   Xiong, X., Martin, S. R., Haire, L. F., Wharton, S. A., Daniels, R. S., Bennett, M. S., McCauley, J. W., Collins, P. J., Walker, P. A., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by an H7N9 influenza virus from humans. Nature, 499, 496-9.

     

    16.   Xiong, X.*, Coombs, P. J.*, Martin, S. R.*, Liu, J., Xiao, H., McCauley, J. W., Locher, K., Walker, P. A., Collins, P. J., Kawaoka, Y., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature, 497, 392-6.

     

    17.  Lin, Y. P.*,Xiong, X.*, Wharton, S. A., Martin, S. R., Coombs, P. J., Vachieri, S. G., Christodoulou, E., Walker, P. A., Liu, J., Skehel, J. J., Gamblin, S. J., Hay, A. J., Daniels, R. S. & McCauley, J. W. (2012). Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.Proc Natl Acad Sci U S A,109, 21474-9.

     

    18.   Xiong, X., Bromley, E. H., Oelschlaeger, P., Woolfson, D. N. & Spencer, J. (2011). Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium. Nucleic Acids Res, 39, 3917-27.

     

    l 共同第一作者。#共同通讯作者。