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专家人才

  • 姓名： 张小飞
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: zhang_xiaofei@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历：

  • 2001-2005 安徽农业大学 植物保护  学士 

    2005-2008 中国科学技术大学生物化学与分子生物学（广州生物医药与健康研究院） 硕士  

    2009-2013 荷兰莱顿大学 分子与细胞生物学 博士 

    2013-2014 荷兰莱顿大学 分子与细胞生物学 博士后 

    2014-2017 荷兰内梅亨大学 分子与细胞生物学 博士后 

    2017-至今  中科院广州生物医药与健康研究院 研究员 

    研究领域：

  • 利用蛋白质谱研究信号通路，泛素化在细胞命运转换中的作用

    承担科研项目情况：

    社会任职：

    获奖及荣誉：

    代表论著：

  •  

    代表论文

    1.       Qiuling Huang, Dajiang Qin, Duanqing Pei, Michiel Vermeulen, Xiaofei Zhang＃. UBE2O and USP7 co-regulate RECQL4 ubiquitination and homologous recombination-mediated DNA repair. FASEB J., 2022 Jan;36(1):e22112

    2.       Yuling Qi, Zhenhuan Feng, Xu Wang, Yaping Chen, Xiaofei Zhang＃. Characterization of the USP10 protein interactome idenfies UPF1 as a USP10-associated protein. Chinese Journal of Biochemistry and Molecular Biology (中国生物化学与分子生物学学报)., 2021 accepted

    3.       Ruona Shi*, Zhenhuan Feng*, Xiaofei Zhang＃. Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses. Genomics, Proteomics & Bioinformatics., 2021; Nov 10;S1672-0229(21)00241-2

    4.       Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang＃. SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation. Cell & Bioscience., 2021 Jul 27;11(1):146

    5.       Pingping Chen*, Hexige Saiyin*, Ruona Shi, Bin Liu, Xu Han, Yuping Gao, Xiantao Ye, Xiaofei Zhang＃, Yu Sun＃.  Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome-acroplaxome complex. Human reproduction., 2021 Aug 18;36(9):2587-2596

    6.       Qiuling Huang, Xiaofei Zhang＃. Emerging Roles and Research Tools of Atypical Ubiquitination. Proteomics., 2020 May; 20 (9)

    7.       Xiaofei Zhang*＃, Arne H. Smits*＃, Gabrielle B.A. van Tilburg*, Huib Ovaa, Wolfgang Huber, Michiel Vermeulen＃. Proteome-wide identification of ubiquitin interactions using UbIA-MS. Nature Protocols., 13, 530-550 (2018)

    8.       Xiaofei Zhang*＃, Arne H. Smits*, Gabrielle B.A. van Tilburg*, Pascal W.T.C. Jansen, Matthew M. Makowski, Huib Ovaa＃, Michiel Vermeulen＃. An Interaction Landscape of Ubiquitin Signaling. Molecular Cell., 65, 941–955 (2017)

    9.       Xiaofei Zhang, Juan Zhang, Andreas Bauer, Long Zhang, Douglas W Selinger, Chris X. Lu, and Peter ten Dijke. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO. J., 2013 Apr 3;32(7):996-1007

    10.    Xiaofei Zhang*, Juan Zhang*, Hans van Dam, Peter ten Dijke. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.  Cell Research., 2013 Mar; 23(3):366-77

    11.    Juan Zhang*, Xiaofei Zhang*, Long Zhang, Fangfang Zhou, Maarten van Dinther, Peter ten Dijke. LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation. J Bone Miner Res., 2012 Oct;27(10):2065-74

    12.    Juan Zhang*, Xiaofei Zhang*, Yunqian Guo*, Liangliang Xu* and Duanqing Pei. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with wiskott-aldrich syndrome protein. J. Biol. Chem., 2009; 284(32):21659-69

    13.    Juan Zhang*, Xiaofei Zhang*, and Duanqing Pei. Mutations of Nuclear Localization Signals in mNANOG generate Dominant Negative Mutants. Chinese Science Bulletin., 2009, Vol. 54 (8): 1361-1368

    14.    Xiaofei Zhang*, Juan Zhang*, Tao Wang, Miguel A. Esteban, and Duanqing Pei. Esrrb activates oct4 transcription and sustains self renewal and pluripotency in embryonic stem cells. J. Biol. Chem., 2008; 283(51):35825-33

    represents equally contribution， ＃represents correspondence

     

    其他论文

    15.    Xueting Xu, Lulu Wang, Tanveer Ahmed, Xintao Cao, Zeyu Zhang, Ming Wang, Yuan Lv, Shahzina Kanwal, Muqddas Tariq, Runxia Lin, Hui Zhang, Yinghua Huang, Hao Peng, Danni Lin, Xue Shi, Didi Geng, Baohua Liu, Xiaofei Zhang, Wen Yi, Yan Qin, Miguel Esteban, and Baoming Qin. mTORC1-eIF4F axis controls paused pluripotency. EMBO reports., 2021 Dec 6; e53081

    16.    Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi. Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis. iScience., 2021 Oct 30;24(12):103396

    17.    Haiyun Wang, Qiuling Huang, Jianhong Xia, Shan Cheng, Duanqing Pei, Xiaofei Zhang, Xiaodong Shu. The E3 ligase MIB1 promotes proteasomal degradation of NRF2 and sensitizes lung cancer cells to ferroptosis. Molecular Cancer Research., 2021; 10.1158/1541-7786.mcr-21-0342

    18.    Sheng Zeng, Jingran Zhang, Mingwei Sun, Xiaofei Zhang, Gregory M Cook, Tianyu Zhang. Nitric oxide-dependent electron transport chain inhibition by the cytochrome bc 1 inhibitor and pretomanid combination kills Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy., 2021 Aug 17;65(9):e0095621

    19.    Junqi Kuang, Ziwei Zhai, Pengli Li, Ruona Shi, Wenjing Guo, Yuxiang Yao, Jing Guo, Guoqing Zhao, Jiangpin He, Shuyang Xu, Chuman Wu, Shengyong Yu, Chunhua Zhou, Linlin Wu, Yue Qin, Baomei Cai, Wei Li, Zichao Wu, Xiaoxi Li, Shilong Chu, Tingting Yang, Bo Wang, Shangtao Cao, Dongwei Li, Xiaofei Zhang, Jiekai Chen, Jing Liu, Duanqing Pei. SS18 regulates pluripotent-somatic transition through phase separation. Nature Communications., 2021 Jul 2;12(1):4090

    20.    Jiadong Liu, Mingwei Gao, Jiangping He, Kaixin Wu, Siyuan Lin, Lingmei Jin, Yaping Chen, He Liu, Junjie Shi, Xiwei Wang, Lei Chang, Yingying Lin, Yu-Li Zhao, Xiaofei Zhang, Man Zhang, Guan-Zheng Luo, Guangming Wu, Duanqing Pei, Jie Wang, Xichen Bao, Jiekai Chen. The RNA m 6 A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature., 591, pages 322–326 (2021)

    21.    Linlin Hou, Yuanjie Wei, Yingying Lin, Xiwei Wang, Yiwei Lai, Menghui Yin, Yanpu Chen, Xiangpeng Guo, Senbin Wu, Yindi Zhu, Jie Yuan, Muqddas Tariq, Na Li, Hao Sun, Huating Wang, Xiaofei Zhang, Jiekai Chen, Xichen Bao, Ralf Jauch. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Res., 2020 Apr 17;48(7):3869-3887

    22.    Kaixin Wu, He Liu, Yaofeng Wang, Jiangping He, Shuyang Xu, Yaping Chen, Junqi Kuang, Jiadong Liu, Lin Guo, Dongwei Li, Ruona Shi, Li Shen, Yangming Wang, Xiaofei Zhang, Jie Wang, Duanqing Pei, and Jiekai Chen. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Cell Reports., 2020 Jan; 30(1), 25-36

    23.    Juan Zhang, Xiaofei Zhang, Feng Xie, Zhengkui Zhang, Hans van Dam, Long Zhang, Fangfang Zhou. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein & cell., 2014 Apr; 5 (7), 503-517

    24.    Fangfang Zhou, Xiaofei Zhang, Hans van Dam, Peter ten Dijke, Huizhe Huang, Long Zhang. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem., 2012 Mar 30;287(14):11002-10

    25.    Jianyong Xu, Huapeng Li, Bo Wang, Yan Xu, Jiayin Yang, Xiaofei Zhang, Sarah K. Harten, Deepa Shukla, Patrick H. Maxwell, Duanqing Pei, and Miguel A. Esteban. VHL Inactivation Induces HEF1 and Aurora Kinase A. J Am Soc Nephrol., 2010 Dec;21(12):2041-6