| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center |
| 英文论文题目: |
Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center |
| 作者: |
Xilong Wang, Yu Luo, Jing Li, Chaoqin Wang, Qianwen Liu, Yimiao He, Shuang Luo* and Qiang Zhu |
| 论文出处: |
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| 刊物名称: |
ACS Catalysis |
| 年: |
2022 |
| 卷: |
12 |
| 期: |
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| 页: |
14918-14925 |
| 联系作者: |
Qiang Zhu |
| 收录类别: |
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| 影响因子: |
13.700 |
| 摘要: |
An example of a parallel kinetic resolution catalyzed by palladium to produce enantioenriched five- and six-membered N-heterocycles in one pot was developed. Dihydroisoquinolines and 1H-isoindoles containing a quaternary stereogenic center were obtained from racemic isocyanides in high yields with good enantioselectivities under mild conditions. A 6,6′-dipropyl substituted SPINOL-derived phosphoramidite was used as the chiral ligand for the palladium catalyst, resulting in regiodivergent and stereospecific cycloimidoylation. Density functional theory (DFT) calculations reveal the origin of the regio- and enantioselectivity during the C(sp2)？H imidoylative cyclization process. KEYWORDS: palladium catalysis, enantioselective imidoylation, parallel kinetic resolution, C？H activation, quaternary stereogenic center |
| 英文摘要: |
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