论文
论文编号: | |
第一作者所在部门: | |
中文论文题目: | Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents |
英文论文题目: | Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents |
作者: | Jing Zhou, Lei Duan, Huaming Chen, Xiaomei Ren, Zhang Zhang, Fengtao Zhou, Jinsong Liu, Duanqing Pei and Ke Ding |
论文出处: | |
刊物名称: | Bioorganic & Medicinal Chemistry Letters |
年: | 2009-9-1 |
卷: | 19 |
期: | 17 |
页: | 5091-94 |
联系作者: | Ke Ding |
收录类别: | |
影响因子: | 2.531 |
摘要: | 2-Piperazinyl naphthoquinones (2) and 2-piperidinyl naphthoquinones (3) were designed and synthesized as new cytotoxic and apoptosis inducing agents by utilizing the anti-parasite drug atovaquone as lead compound. Several compounds displayed significantly improved cytotoxic activities against a panel of cancer cell lines than that of atovaquone. These compounds also induced apoptosis through activating pro-apoptotic caspases 9 and 3. |
英文摘要: | |
外单位作者单位: | |
备注: |